Breast Cancer Research

Table 4 Association of SLC7A5 mRNA expression and the expression of other molecular biomarkers in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) series

From: The amino acid transporter SLC7A5 confers a poor prognosis in the highly proliferative breast cancer subtypes and is a key therapeutic target in luminal B tumours

SLC7A5 mRNA expression
	Number (%)	Mean	t test	p value	Adjusted p value
Estrogen receptor
Negative	474 (24)	9.543	26.90	5.6 × 10^{− 113}	<0.0001
Positive	1506 (76)	7.943	26.90	5.6 × 10^{− 113}	<0.0001
Progesterone receptor
Negative	940 (47)	8.862	18.73	1.07 × 10⁻⁷¹	<0.0001
Positive	1040 (53)	7.841	18.73	1.07 × 10⁻⁷¹	<0.0001
HER2
Negative	1733 (88)	8.216	−12.35	1.1 × 10⁻²⁹	<0.0001
Positive	247 (12)	9.095	−12.35	1.1 × 10⁻²⁹	<0.0001
Triple negative (ER-, PR-, HER2-)
No	1660 (84)	8.065	−22.12	1.9 × 10⁻⁷³	<0.0001
Yes	320 (16)	9.676	−22.12	1.9 × 10⁻⁷³	<0.0001
Basal phenotype
No	1645 (83)	8.036	−25.70	1.5 × 10⁻⁹¹	<0.0001
Yes	329 (17)	9.788	−25.70	1.5 × 10⁻⁹¹	<0.0001
TP53 mutation
Wild-type	721 (88)	8.132	−7.47	1.2 × 10⁻¹¹	<0.0001
Mutation	99 (12)	9.148	−7.47	1.2 × 10⁻¹¹	<0.0001

ER oestrogen receptor, PgR progesterone receptor, HER2 human epidermal growth factor receptor 2
p value in bold in these tables means statistically significant associations

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ISSN: 1465-542X

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