Table 2 Copy number aberrations of SLC7A5 in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) breast cancer series and their association with clinicopathological parameters, MYC copy number aberrations and breast cancer subtypes
SLC7A5 copy number | ||||||||
|---|---|---|---|---|---|---|---|---|
Gain | Loss | |||||||
|  | No, number (%) | Yes, number (%) | χ2 (p value) | Adjusted p value | No, number (%) | Yes, number (%) | χ2 (p value) | Adjusted p value |
Age (years) | ||||||||
 ≥50 | 1520 (97.7) | 36 (2.3) | 0.405 (0.524) | 1.572 | 1098 (70.6) | 458 (29.4) | 27.479 (1.5 × 10− 7) | <0.0001 |
 ˂50 | 372 (97.1) | 11 (2.9) | 321 (83.8) | 62 (16.2) | ||||
Tumour size | ||||||||
 ≥2.0 cm | 1291 (97.0) | 40 (3.0) | 5.226 (0.022) | 0.132 | 976 (73.3) | 355 (26.7) | 0.094 (0.759) | 0.282 |
 ˂2.0 cm | 614 (98.7) | 8 (1.3) | 452 (72.7) | 170 (27.3) | ||||
Tumour grade | ||||||||
 1 | 170 (100.0) | 0 (0.0) | 10.154 (0.006) | 0.042 | 99 (58.2) | 71 (41.8) | 107.36 4.8 × 10−24 | <0.0001 |
 2 | 756 (98.2) | 14 (1.8) | 495 (64.3) | 275 (35.7) | ||||
 3 | 918 (96.4) | 34 (3.6) | 799 (83.9) | 153 (16.1) | ||||
Lymph node stage | ||||||||
 1 | 1012 (97.8) | 23 (2.2) | 0.474 (0.789) | 1.578 | 726 (70.1) | 309 (29.9) | 10.425 (0.005) | 0.02 |
 2 | 606 (97.4) | 16 (2.6) | 480 (77.2) | 142 (22.8) | ||||
 3 | 307 (97.2) | 9 (2.8) | 237 (75.0) | 79 (25.0) | ||||
Nottingham Prognostic Index | ||||||||
 Good | 668 (98.2) | 12 (1.8) | 2.602 (0.272) | 0.080 | 418 (61.5) | 262 (38.5) | 76.132 (2.9 × 10−17) | <0.0001 |
 Moderate | 1071 (97.3) | 30 (2.7) | 864 (78.5) | 237 (21.5) | ||||
 Poor | 192 (96.5) | 7 (3.5) | 168 (84.4) | 31 (15.6) | ||||
Histological type | ||||||||
 Ductal | 1500 (97.2) | 44 (2.8) | 6.880 (0.230) | 1.150 | 1154 (74.7) | 390 (25.3) | 29.544 (0.00001) | 0.0001 |
 Lobular | 145 (98.6) | 2 (1.4) | 88 (59.9) | 59 (40.1) | ||||
 Medullary | 30 (93.8) | 2 (6.3) | 30 (93.8) | 2 (6.2) | ||||
 Miscellaneous | 12 (100.0) | 0 (0.0) | 9 (75.0) | 3 (25.0) | ||||
 Special type | 113 (100.0) | 0 (0.0) | 74 (66.8) | 39 (33.2) | ||||
PAM50 subtype | ||||||||
 Luminal A | 710 (98.9) | 8 (1.1) | 40.515 (3.3 × 10−8) | <0.0001 | 423 (58.9) | 295 (41.1) | 248.3 (1.4 × 10−52) | <0.0001 |
 Luminal B | 477 (97.7) | 11 (2.3) | 312 (63.9) | 176 (36.1) | ||||
 Basal | 305 (92.7) | 24 (7.3) | 319 (97.0) | 10 (3.0) | ||||
 HER2+ | 235 (97.9) | 5 (2.1) | 219 (91.3) | 21 (8.7) | ||||
 Normal-like | 198 (99.5) | 1 (0.5) | 172 (11.9) | 27 (5.1) | ||||
MYC gain | ||||||||
 No | 1228 (98.9) | 14 (1.1) | 25.0 (5.5 × 10−7) | <0.0001 | 1446 (73.3) | 528 (26.7) | 0.132 (0.716) | 1.432 |
 Yes | 703 (95.3) | 35 (4.7) | 4 (66.7) | 2 (33.3) | ||||