Characteristics | No. of patients (N = 721) | % |
---|---|---|
Breast cancer type | ||
 Invasive ductal | 664 | 92 |
 Invasive lobular | 9 | 1 |
 Mixed ductal/lobular | 14 | 2 |
 Breast cancer, NOSa | 16 | 2 |
 Other | 18 | 3 |
Age, years | ||
 21–40 | 154 | 21 |
 41–60 | 449 | 63 |
 > 60 | 118 | 16 |
Race | ||
 White | 423 | 59 |
 Hispanic | 136 | 19 |
 Black | 109 | 15 |
 Asian | 45 | 6 |
 Other | 8 | 1 |
Menopausal status | ||
 Unknown | 1 | 0 |
 Premenopausal | 314 | 44 |
 Pregnant | 3 | 0 |
 Perimenopausal | 14 | 2 |
 Postmenopausal | 389 | 54 |
Clinical stage | ||
 IIA | 292 | 41 |
 IIB | 153 | 21 |
 IIIA | 78 | 11 |
 IIIB | 66 | 9 |
 IIIC | 132 | 19 |
Estrogen receptor status | ||
 Unknown | 15 | 2 |
 Negative | 454 | 63 |
 Positive | 252 | 35 |
Progesterone receptor status | ||
 Unknown | 19 | 3 |
 Negative | 526 | 73 |
 Positive | 176 | 24 |
HER2 status | ||
 Negative | 286 | 40 |
 Positive | 312 | 43 |
 Equivocal | 123 | 17 |
Tumor subtype | ||
 Unknown | 18 | 3 |
 HR | 157 | 22 |
 TN | 236 | 33 |
HER2-amplified | 310 | 43 |
 HR+ | 128 | 41 |
 HR− | 178 | 57 |
 Unknown HR | 4 | 1 |
Neoadjuvant chemotherapy | ||
 A no T | 56 | 8 |
 A + T | 367 | 51 |
 AT + HER2 | 227 | 31 |
 PC | 71 | 10 |
HER2+ patient regimens | ||
 HER2-containing regimen | 247 | 80 |
 No HER2 | 60 | 20 |
Length of NACT therapy | ||
 0–4 months | 64 | 9 |
 4 & 7 months | 570 | 79 |
 7 months | 87 | 12 |
Neoadjuvant hormonal therapy | ||
 Yes | 12 | 0 |
 No | 715 | 100 |
Neoadjuvant radiation therapy | ||
 Yes | 1 | 0 |
 No | 720 | 100 |
Adjuvant chemotherapy | ||
 Yes | 196 | 27 |
 No | 525 | 73 |
Adjuvant endocrine therapy | ||
 Yes | 261 | 36 |
 No | 460 | 64 |
Adjuvant radiation therapy | ||
 Yes | 559 | 78 |
 No | 162 | 22 |
Outcomes | ||
 Progression | 63 | 9 |
 Death (any cause) | 62 | 9 |
 Progression + death | 40 | 6 |
 Death without progression | 22 | 3 |
Site of metastasis | ||
 Distant first | 41 | 65 |
  Brain-only | 13 | 32 |
  Bone-only | 4 | 10 |
  Liver-only | 4 | 10 |
  Lung-only | 3 | 7 |
  Mixed/other | 17 | 41 |
 Local first | 11 | 17 |
  Chest wall-only | 1 | 9 |
  Ipsilateral breast-only | 10 | 91 |
 Both local and distant | 11 | 17 |
  Concurrenta | 6 | 55 |
  Sequential | 5 | 45 |