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Table 3 Mean urinary estrone 1-glucuronide levels and 95% CIs across stages of puberty, according to Pubertal Development Scale and Sexual Maturation Scale in the LEGACY Girls Study

From: Comparison of methods to assess onset of breast development in the LEGACY Girls Study: methodological considerations for studies of breast cancer

Stage

PDSa

SMSb

Clinical TSc

No. of subjects

Mean (ng/ml)

95% CI

No. of subjects

Mean (ng/ml)

95% CI

No. of subjects

Mean (ng/ ml)

95% CI

1

96

1.25

1.11–1.39

116

1.34

1.21–1.47

103

1.29

1.16–1.43

2

36

1.91

1.51–2.32

20

2.07

1.61–2.54

36

1.96

1.56–2.36

3

21

2.34

1.87–2.81

13

2.30

1.76–2.83

11

2.31

1.74–2.89

4

0

   

4

2.76

1.92–3.59

3

3.94

1.98–3.87

2–4

57

2.07

1.70–2.44

37

2.23

1.83–2.62

50

2.10

1.72–2.47

  1. Abbreviations: PDS Pubertal Development Scale, SMS Sexual Maturation Scale, TS Tanner scale
  2. aPDS is a questionnaire-based assessment of breast development without pictures
  3. bSMS is a questionnaire-based assessment of breast development that uses pictures to illustrate the five Tanner Stages of breast development
  4. cClinical TS is a physical examination of breast development and rated according to the five Tanner stages of breast development