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Table 3 Mean urinary estrone 1-glucuronide levels and 95% CIs across stages of puberty, according to Pubertal Development Scale and Sexual Maturation Scale in the LEGACY Girls Study

From: Comparison of methods to assess onset of breast development in the LEGACY Girls Study: methodological considerations for studies of breast cancer

Stage PDSa SMSb Clinical TSc
No. of subjects Mean (ng/ml) 95% CI No. of subjects Mean (ng/ml) 95% CI No. of subjects Mean (ng/ ml) 95% CI
1 96 1.25 1.11–1.39 116 1.34 1.21–1.47 103 1.29 1.16–1.43
2 36 1.91 1.51–2.32 20 2.07 1.61–2.54 36 1.96 1.56–2.36
3 21 2.34 1.87–2.81 13 2.30 1.76–2.83 11 2.31 1.74–2.89
4 0     4 2.76 1.92–3.59 3 3.94 1.98–3.87
2–4 57 2.07 1.70–2.44 37 2.23 1.83–2.62 50 2.10 1.72–2.47
  1. Abbreviations: PDS Pubertal Development Scale, SMS Sexual Maturation Scale, TS Tanner scale
  2. aPDS is a questionnaire-based assessment of breast development without pictures
  3. bSMS is a questionnaire-based assessment of breast development that uses pictures to illustrate the five Tanner Stages of breast development
  4. cClinical TS is a physical examination of breast development and rated according to the five Tanner stages of breast development
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