Comparison of methods to assess onset of breast development in the LEGACY Girls Study: methodological considerations for studies of breast cancer

Table 3 Mean urinary estrone 1-glucuronide levels and 95% CIs across stages of puberty, according to Pubertal Development Scale and Sexual Maturation Scale in the LEGACY Girls Study

Stage	PDS^a			SMS^b			Clinical TS^c
Stage	No. of subjects	Mean (ng/ml)	95% CI	No. of subjects	Mean (ng/ml)	95% CI	No. of subjects	Mean (ng/ ml)	95% CI
1	96	1.25	1.11–1.39	116	1.34	1.21–1.47	103	1.29	1.16–1.43
2	36	1.91	1.51–2.32	20	2.07	1.61–2.54	36	1.96	1.56–2.36
3	21	2.34	1.87–2.81	13	2.30	1.76–2.83	11	2.31	1.74–2.89
4	0			4	2.76	1.92–3.59	3	3.94	1.98–3.87
2–4	57	2.07	1.70–2.44	37	2.23	1.83–2.62	50	2.10	1.72–2.47

Abbreviations: PDS Pubertal Development Scale, SMS Sexual Maturation Scale, TS Tanner scale
^aPDS is a questionnaire-based assessment of breast development without pictures
^bSMS is a questionnaire-based assessment of breast development that uses pictures to illustrate the five Tanner Stages of breast development
^cClinical TS is a physical examination of breast development and rated according to the five Tanner stages of breast development

ISSN: 1465-542X