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Table 2 Accuracy of Pubertal Development Scale method of assessing breast onset compared with clinical Tanner scale, by sample characteristics in the LEGACY Girls Study

From: Comparison of methods to assess onset of breast development in the LEGACY Girls Study: methodological considerations for studies of breast cancer

Description PDSa vs clinical TSb
2+ vs 1
No. of subjects Accuracy (%) Kappa value 95% CI Sensitivity Specificity
All ages combined 282 87.9 0.8 0.7–0.9 86.6 89.6
 Daughter aged < 10 years 165 91.9 0.6 0.4–0.8 62.5 95.8
 Daughter aged ≥ 10 years 117 83.8 0.4 0.2–0.6 91.8 45
Family history
 Positive 122 89.3 0.8 0.6–1.0 86.6 92.2
 Negative 155 87.5 0.7 0.5–0.9 86.7 88
BMI percentilec
 BMI ≥ 85th percentile 50 84.6 0.7 0.4–0.9 96.9 65
 BMI < 85th percentile 223 89.1 0.8 0.7–0.9 83 93.1
Race/ethnicity
 White non-Hispanic 189 87.9 0.7 0.6–0.8 100 100
 Hispanic 60 90 0.8 0.5–1.1 84.8 89.9
Other (black, Asian, other) 33 87.9 0.8 0.5–1.1 81.3 94.1
Site
 New York 135 89.6 0.8 0.6–1.0 86.7 92
 Utah 147 86.4 0.7 0.5–0.9 84.5 87.6
  1. Abbreviations: BMI Body mass index, PDS Pubertal Development Scale, TS Tanner scale
  2. aPDS is a questionnaire-based assessment of breast development without pictures
  3. bClinical TS is a physical examination of breast development and rated according to the five Tanner stages of breast development
  4. cMissing BMI for 19 girls
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Breast Cancer Research

ISSN: 1465-542X

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