|
Covariable
|
Distant disease-free survivalHR (95% CI)
|
P
|
|---|
|
CXCL13 expression
|
|
≤ Median
|
ref.
| |
|
> Median
|
0.44 (0.29–0.67)
|
< 0.001
|
|
FOXP3 expression
|
|
≤ Median
|
ref.
|
0.400
|
|
> Median
|
1.20 (0.78–1.84)
| |
|
CD4 expression
|
|
≤ Median
|
ref.
|
0.396
|
|
> Median
|
1.89 (0.80–1.78)
| |
|
Age at study entry
|
|
≤50 years
|
Ref.
|
0.516
|
|
>50 years
|
0.88 (0.62–1.27)
| |
|
Tumor size
| |
0.105
|
|
pT1
|
Ref.
| |
|
pT2
|
1.22 (0.82–1.81)
|
0.330
|
|
pT3
|
1.89 (1.05–3.40)
|
0.034
|
|
Axillary nodal status
| |
< 0.001
|
|
pN0
|
Ref.
| |
|
pN1
|
4.51 (1.94–10.52)
|
< 0.001
|
|
pN2
|
14.27 (4.78–42.71)
|
< 0.001
|
|
Histological grade
| |
0.229
|
|
I
|
Ref.
| |
|
II
|
2.06 (0.86–4.95)
|
0.105
|
|
III
|
2.22 (0.88–5.52)
|
0.088
|
|
Molecular subtype
| |
< 0.001
|
|
Luminal A-like
|
Ref.
| |
|
Luminal B-like
|
1.79 (1.01–3.14)
|
0.045
|
|
Triple-negative
|
4.18 (2.30–7.59)
|
< 0.001
|
|
HER2-positive
|
2.71 (1.56–4.68)
|
< 0.001
|
- Abbreviations: CD4 cluster of differentiation 4, CI confidence interval, CXCL13 C-X-C motif chemokine ligand 13, FOXP3 forkhead box P3, HER2 human epidermal growth factor receptor 2, HR hazard ratio
