Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density

Breast Cancer Research

Table 3 Candidate proteins without annotated gene expression in breast tissue

					Sample set 1, N = 729		Sample set 2, N = 600		All samples
Gene	Gene description	Annotated protein function^a	HPA	ENSG	P value	Effect size	P value	Effect size	Trend adjusted	Adjusted p value^b
AGER	Advanced glycosylation end-product-specific receptor	Multi-ligand receptor member of immunoglobulin superfamily cell surface receptors	HPA069474	ENSG00000204305	0.0004	0.09	0.002	0.10	+	0.00001
CYP2S1	Cytochrome P450 family 2 subfamily S member 1	Monooxygenase superfamily of enzymes, unclear function in humans	HPA037692	ENSG00000167600	0.008	0.09	0.03	0.07	+	0.002
DEFB134	Defensin beta 134	Secreted antimicrobial protein	HPA044494	ENSG00000205882	0.03	0.13	0.008	0.07	+	0.03
CST6	Cystein E/M	Secreted proteinase inhibitor with protective and anti-metastatic functions	HPA044963	ENSG00000175315	0.02	−0.07	0.009	−0.09	–	0.002
DLX1	Distal-less homeobox 1	Member of homeobox transcription factor gene family	HPA007175	ENSG00000144355	0.02	−0.11	0.003	−0.14	–	0.02
F2	Coagulation factor II, thrombin	Part of first step of coagulation cascade.	HPA051476	ENSG00000180210	0.01	−0.17	0.01	−0.11	–	0.01
IL4	Interleukin 4	Pleiotropic cytokine produced by activated T cells	HPA042270	ENSG00000113520	0.002	−0.20	0.0001	−0.14	–	0.000003
LIN28B	Lin-28 homolog B	Member of lin-28 family of RNA binding proteins	HPA061745	ENSG00000187772	0.03	−0.08	0.01	−0.10	–	0.003
PSMA8	Proteasome subunit alpha 8	Peptide cleaving proteasome involved in histone	HPA049377	ENSG00000154611	0.01	−0.14	0.01	−0.11	–	0.01

ENSG, Ensembl genes
^aInformation extracted from the Human Protein Atlas (HPA) [24]
^bFisher’s combined probability test, adjusted for multiple testing (Benjamini and Hochberg method)

ISSN: 1465-542X