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Table 3 Candidate proteins without annotated gene expression in breast tissue

From: Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density

      Sample set 1, N = 729 Sample set 2, N = 600 All samples
Gene Gene description Annotated protein functiona HPA ENSG P value Effect size P value Effect size Trend adjusted Adjusted
p valueb
AGER Advanced glycosylation end-product-specific receptor Multi-ligand receptor member of immunoglobulin superfamily cell surface receptors HPA069474 ENSG00000204305 0.0004 0.09 0.002 0.10 + 0.00001
CYP2S1 Cytochrome P450 family 2 subfamily S member 1 Monooxygenase superfamily of enzymes, unclear function in humans HPA037692 ENSG00000167600 0.008 0.09 0.03 0.07 + 0.002
DEFB134 Defensin beta 134 Secreted antimicrobial protein HPA044494 ENSG00000205882 0.03 0.13 0.008 0.07 + 0.03
CST6 Cystein E/M Secreted proteinase inhibitor with protective and anti-metastatic functions HPA044963 ENSG00000175315 0.02 −0.07 0.009 −0.09 0.002
DLX1 Distal-less homeobox 1 Member of homeobox transcription factor gene family HPA007175 ENSG00000144355 0.02 −0.11 0.003 −0.14 0.02
F2 Coagulation factor II, thrombin Part of first step of coagulation cascade. HPA051476 ENSG00000180210 0.01 −0.17 0.01 −0.11 0.01
IL4 Interleukin 4 Pleiotropic cytokine produced by activated T cells HPA042270 ENSG00000113520 0.002 −0.20 0.0001 −0.14 0.000003
LIN28B Lin-28 homolog B Member of lin-28 family of RNA binding proteins HPA061745 ENSG00000187772 0.03 −0.08 0.01 −0.10 0.003
PSMA8 Proteasome subunit alpha 8 Peptide cleaving proteasome involved in histone HPA049377 ENSG00000154611 0.01 −0.14 0.01 −0.11 0.01
  1. ENSG, Ensembl genes
  2. aInformation extracted from the Human Protein Atlas (HPA) [24]
  3. bFisher’s combined probability test, adjusted for multiple testing (Benjamini and Hochberg method)
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