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Table 2 Protein profiles associated with area-based mammographic breast density in both study sets (p < 0.05)

From: Affinity proteomic profiling of plasma for proteins associated to area-based mammographic breast density

      Sample set 1, N = 729 Sample set 2, N = 600 All samples
Gene Gene description Annotated protein functiona HPA ENSG P value Effect size P value Effect size Trend Adjusted p valueb
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 Membrane-associated transport protein HPA031981 ENSG00000121270 0.002 0.08 0.00003 0.09 + 0.002
TNFRSF10D Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain Transmembrane signalling receptor regulating apoptosis HPA065387 ENSG00000173530 0.002 0.16 0.03 0.08 + 0.002
F11R F11 receptor Epithelial cell-cell adhesion molecule. HPA061700 ENSG00000158769 0.02 0.11 0.02 0.10 + 0.004
ERRF/C1orf64 ER-related factor (chromosome 1 open reading frame 64) Steroid receptor associated and regulated protein HPA026676 ENSG00000183888 0.007 0.13 0.002 0.11 + 0.007
ACOX2 Acyl-CoA oxidase 2, branched chain Acyl-Coenzyme A oxidase involved in the degradation of long branched fatty acids HPA064845 ENSG00000168306 0.003 −0.16 0.0001 −0.15 0.000005
ITGB6 Integrin, beta 6 Adhesion receptor signalling molecule HPA023626 ENSG00000115221 0.000003 − 0.12 0.0009 − 0.15 0.00003
CFLAR CASP8 and FADD-like apoptosis regulator Cystein-type peptidase regulating apoptosis HPA050009 ENSG00000003402 0.003 −0.12 0.003 −0.14 0.00009
FANCD2 Fanconi anaemia, complementation group D2 Complementation protein involved in homology-directed DNA repair HPA054101 ENSG00000144554 0.0004 −0.24 0.02 −0.08 0.0001
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 Adapter protein in signal transduction pathways HPA001577 ENSG00000160691 0.0002 −0.20 0.008 −0.10 0.0002
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 Signal transduction protein regulating apoptosis HPA040735 ENSG00000068028 0.05 −0.10 0.02 −0.07 0.008
IRX5 Iroquois homeobox 5 Transcription factor involved in cell differentiation and cell cycle HPA047130 ENSG00000176842 0.04 −0.10 0.02 −0.09 0.04
  1. aInformation extracted from the Human Protein Atlas [24]. More detailed descriptions of protein functions are given in “Discussion” and Additional file 2
  2. bFisher’s combined probability test, adjusted for multiple testing (Benjamini and Hochberg method)
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