Table 2 Protein profiles associated with area-based mammographic breast density in both study sets (p < 0.05)

ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11

Membrane-associated transport protein

HPA031981

ENSG00000121270

0.002

0.08

0.00003

0.09

+

0.002

TNFRSF10D

Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain

Transmembrane signalling receptor regulating apoptosis

HPA065387

ENSG00000173530

0.002

0.16

0.03

0.08

+

0.002

F11R

F11 receptor

Epithelial cell-cell adhesion molecule.

HPA061700

ENSG00000158769

0.02

0.11

0.02

0.10

+

0.004

ERRF/C1orf64

ER-related factor (chromosome 1 open reading frame 64)

Steroid receptor associated and regulated protein

HPA026676

ENSG00000183888

0.007

0.13

0.002

0.11

+

0.007

ACOX2

Acyl-CoA oxidase 2, branched chain

Acyl-Coenzyme A oxidase involved in the degradation of long branched fatty acids

HPA064845

ENSG00000168306

0.003

−0.16

0.0001

−0.15

–

0.000005

ITGB6

Integrin, beta 6

Adhesion receptor signalling molecule

HPA023626

ENSG00000115221

0.000003

− 0.12

0.0009

− 0.15

–

0.00003

CFLAR

CASP8 and FADD-like apoptosis regulator

Cystein-type peptidase regulating apoptosis

HPA050009

ENSG00000003402

0.003

−0.12

0.003

−0.14

–

0.00009

FANCD2

Fanconi anaemia, complementation group D2

Complementation protein involved in homology-directed DNA repair

HPA054101

ENSG00000144554

0.0004

−0.24

0.02

−0.08

–

0.0001

SHC1

SHC (Src homology 2 domain containing) transforming protein 1

Adapter protein in signal transduction pathways

HPA001577

ENSG00000160691

0.0002

−0.20

0.008

−0.10

–

0.0002

RASSF1

Ras association (RalGDS/AF-6) domain family member 1

Signal transduction protein regulating apoptosis

HPA040735

ENSG00000068028

0.05

−0.10

0.02

−0.07

–

0.008

IRX5

Iroquois homeobox 5

Transcription factor involved in cell differentiation and cell cycle

HPA047130

ENSG00000176842

0.04

−0.10

0.02

−0.09

–

0.04