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Table 3 Frequency of six-marker immunohistochemistry-defined subtypesa, overall and by study site in the AMBER consortium

From: Frequency of breast cancer subtypes among African American women in the AMBER consortium

 

IHC-based definitiona

Overall

n (%)

CBCS

n (%)

WCHS

n (%)

BWHS

n (%)

Luminal A

HR ≥10%, Ki67 <7%

512 (37)

233 (32)

146 (42)

133 (46)

Luminal B

HR ≥10%, Ki67 ≥7%

333 (25)

212 (29)

73 (21)

48 (17)

ER-/HER2+

ER <10%, HER2+

111 (8)

52 (7)

32 (9)

27 (9)

Basal-like

HR <10%, HER2-, antigenicity+

425 (31)

247 (33)

99 (28)

79 (28)

Total

 

1381

744

350

287

Unclassifiedb

 

171

75

57

39

  1. CBCS percentages are weighted for study sampling scheme
  2. ER estrogen receptor, HER2 human epidermal growth factor receptor 2, IHC immunohistochemistry, HR hormone receptor, CBCS Carolina Breast Cancer Study, WCHS Women’s Circle of Health Study, BWHS Black Women’s Health Study
  3. aAntigenicity+ = CK5/6 ≥1% or EGFR ≥1%
  4. bTumors with five-marker negative (n = 7), HER2-equivocal (n = 81), and missing biomarker (n = 83) status remained unclassified