Fig. 2

False-positive magnetic resonance imaging (MRI) screening diagnosis. Screening breast MRI (a and b) in a 51-year-old woman at average risk undergoing screening MRI. MRI showed moderate background enhancement (American College of Radiology C) and a nonmass enhancement with segmental distribution in the right breast (arrow in a). MRI-guided vacuum biopsy was performed (c–f). Histology revealed atypical ductal hyperplasia (ADH), flat epithelial atypia, and sclerosing adenosis (g). Immunohistochemical staining was needed to confirm ADH (h). The patient subsequently underwent open surgery, which confirmed the presence of ADH; no ductal carcinoma in situ or invasive cancer was found. The patient has been in follow-up, including serial MRI, for 2 years, so far without a diagnosis of invasive cancer. a and b Screening diagnostic breast MRI. First postcontrast subtracted (a) and nonsubtracted images (b). c–f MRI-guided vacuum biopsy of the segmental nonmass enhancement in the right breast (black arrows in d). First postcontrast subtracted (c) and nonsubtracted images (d), T2-weighted turbo spin echo (TSE) before (e) and after (f) biopsy with the biopsy cavity, which demonstrates successful biopsy (yellow arrow). g and h Histology after H&E staining (g) and immunohistochemical staining with cytokeratin 5/6 (CK5/6) (h). a and b Screening diagnostic breast MRI. First postcontrast subtracted (a) and nonsubtracted image (b). c–f MRI-guided vacuum biopsy of the segmental nonmass enhancement in the right breast (black arrows in d). First postcontrast subtracted (c) and nonsubtracted images (d), T2-weighted TSE before (e) and after (f) biopsy with the biopsy cavity, which demonstrates successful biopsy (yellow arrow). g and h Histology after H&E staining (g) and immunohistochemical staining with CK5/6 (h)