Fig. 7
From: Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion
A molecular components signature of plau/plaur/vtn/fosl1 is prognostic in human breast cancer. a Kaplan meier analysis of overall survival in patients with breast cancer separated by high or low fosl1 expression. b Activity analysis of a Fos-related antigen 1 (FRA-1) transcriptional signature in breast cells with elevated phosphorylated FRA-1 (High pFRA-1 cell lines) or low levels of FRA-1 phosphorylation (Low pFRA-1 Cell lines). The activity index indicates the probability that a given breast cancer cell line will be positive for the FRA-1 signature. c Kaplan-Meier analysis in breast cancer patients using an FRA-1 transcriptional activity signature composed of the top 65 genes regulated by FRA-1 (see Table 1). Patients are divided into high (red) or low (black) transcriptional activity. d Correlation between fosl1 expression and FRA-1 transcriptional activity signature. e Correlation between the FRA-1 transcriptional activity signature and molecular component signature composed of genes encoding FRA-1 (fosl1) and upstream signaling proteins (plau/plaur/vtn). f Kaplan-Meier analysis of breast cancer patients divided into high (red) and low (black) reveals that expression of a molecular component signature is prognostic for reduced overall survival (g), recurrence-free survival (RFS) and (h) distant metastasis-free survival (DMFS). KMplot.com dataset was used in all analysis apart from b where the Neve et al. dataset was used