Fig. 6

Number of nest association with TTDM in grade 1 ER⁺/HER2^– invasive carcinomas NST and mixed NST/special subtype. a 18-mm tumour with nest number = 217; patient diagnosed with lung metastasis 31 months postoperatively; patient died from breast cancer at 36 months postoperatively. b 25-mm tumour with nest number = 22; patient alive after 270 months of follow-up without metastasis