Table 3 Density measures by categorical scales
From: A comparison of five methods of measuring mammographic density: a case-control study
Subset with data for all methodsb | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Controls | Cases | Univariate | Adjusteda | Controls | Cases | Univariate | Adjusteda | |||||||||
N | Percent | N | Percent | OR | 95% CI | OR | 95% CI | N | Percent | N | Percent | OR | 95% CI | OR | 95% CI | |
Study 1 | ||||||||||||||||
VAS (mean) - Boyd categories (combining > 50–75% and > 75%) | ||||||||||||||||
≥ 0–10% | 208 | (18.9) | 29 | (9.1) | 1.00 | (referent) | 1.00 | (referent) | 176 | (21.1) | 25 | (8.3) | 1.00 | (referent) | 1.00 | (referent) |
> 10–25% | 436 | (39.7) | 115 | (35.9) | 2.17 | (1.37–3.42) | 2.16 | (1.37–3.40) | 331 | (39.7) | 111 | (36.9) | 2.67 | (1.63–4.38) | 2.65 | (1.62–4.34) |
> 25–50% | 379 | (34.5) | 133 | (41.6) | 3.25 | (2.05–5.18) | 3.20 | (2.01–5.09) | 277 | (33.3) | 125 | (41.5) | 3.95 | (2.38–6.54) | 3.84 | (2.31–6.36) |
> 50% | 75 | (6.8) | 43 | (13.4) | 6.92 | (3.74–12.79) | 6.73 | (3.64–12.45) | 49 | (5.9) | 40 | (13.3) | 8.30 | (4.28–16.07) | 8.02 | (4.13–15.56) |
Volpara Density Grades 4th Edition | ||||||||||||||||
1 (<4.5) | 496 | (45.2) | 124 | (34.0) | 1.00 | (referent) | 1.00 | (referent) | 400 | (48.0) | 108 | (35.9) | 1.00 | (referent) | 1.00 | (referent) |
2 (4.5–<7.5) | 339 | (30.9) | 131 | (35.9) | 1.78 | (1.31–2.41) | 1.74 | (1.29–2.37) | 258 | (31.0) | 113 | (37.5) | 1.90 | (1.35–2.66) | 1.88 | (1.34–2.63) |
3 (7.5–<15.5) | 229 | (20.9) | 85 | (23.3) | 1.85 | (1.29–2.64) | 1.86 | (1.30–2.68) | 153 | (18.4) | 64 | (21.3) | 1.92 | (1.28–2.90) | 1.94 | (1.29–2.94) |
4 (15.5+) | 34 | (3.1) | 25 | (6.8) | 4.18 | (2.24–7.77) | 4.07 | (2.18–7.60) | 22 | (2.6) | 16 | (5.3) | 3.73 | (1.80–7.75) | 3.58 | (1.72–7.44) |
Volpara Density Grades 5th Edition | ||||||||||||||||
1 (< 3.5) | 274 | (25.0) | 62 | (17.0) | 1.00 | (referent) | 1.00 | (referent) | 216 | (25.9) | 50 | (16.6) | 1.00 | (referent) | 1.00 | (referent) |
2 (3.5–<7.5) | 561 | (51.1) | 193 | (52.9) | 1.68 | (1.20–2.34) | 1.68 | (1.20–2.35) | 442 | (53.1) | 171 | (56.8) | 1.88 | (1.29–2.73) | 1.89 | (1.30–2.75) |
3 (7.5–<15.5) | 229 | (20.9) | 85 | (23.3) | 2.00 | (1.32–3.02) | 2.04 | (1.34–3.09) | 153 | (18.4) | 64 | (21.3) | 2.22 | (1.38–3.57) | 2.27 | (1.41–3.66) |
4 (15.5+) | 34 | (3.1) | 25 | (6.8) | 4.44 | (2.31–8.54) | 4.39 | (2.28–8.48) | 22 | (2.6) | 16 | (5.3) | 4.26 | (1.98–9.17) | 4.14 | (1.92–8.95) |
Quantized density (BIRADS) | ||||||||||||||||
1 | 54 | (4.9) | 27 | (7.4) | 1.00 | (referent) | 1.00 | (referent) | 47 | (5.6) | 21 | (7.0) | 1.00 | (referent) | 1.00 | (referent) |
2 | 682 | (62.2) | 220 | (60.3) | 0.63 | (0.39–1.02) | 0.61 | (0.38–0.99) | 530 | (63.6) | 193 | (64.1) | 0.85 | (0.50–1.44) | 0.80 | (0.47–1.37) |
3 | 317 | (28.9) | 102 | (27.9) | 0.63 | (0.37–1.05) | 0.58 | (0.34–0.99) | 226 | (27.1) | 75 | (24.9) | 0.77 | (0.43–1.38) | 0.71 | (0.39–1.28) |
4 | 44 | (4.0) | 16 | (4.4) | 0.71 | (0.33–1.52) | 0.62 | (0.29–1.33) | 30 | (3.6) | 12 | (4.0) | 0.92 | (0.39–2.17) | 0.79 | (0.33–1.88) |
Densitas: BIRADS 4 | ||||||||||||||||
0–24 | 387 | (37.4) | 105 | (35.2) | 1.00 | (referent) | 1.00 | (referent) | 326 | (39.1) | 94 | (31.2) | 1.00 | (referent) | 1.00 | (referent) |
25–50 | 599 | (57.8) | 219 | (60.8) | 1.53 | (1.15–2.04) | 1.48 | (1.11–1.98) | 470 | (56.4) | 186 | (61.8) | 1.53 | (1.12–2.08) | 1.48 | (1.09–2.03) |
51+ | 50 | (4.8) | 36 | (10.0) | 3.46 | (2.04–5.87) | 3.21 | (1.88–5.47) | 35 | (4.2) | 21 | (7.0) | 2.47 | (1.34–4.55) | 2.33 | (1.26–4.30) |
Densitas: BIRADS 5 | ||||||||||||||||
A | 194 | (18.7) | 46 | (12.8) | 1.00 | (referent) | 1.00 | (referent) | 171 | (20.5) | 37 | (12.3) | 1.00 | (referent) | 1.00 | (referent) |
B | 552 | (53.3) | 191 | (53.1) | 1.58 | (1.08–2.30) | 1.50 | (1.03–2.19) | 446 | (53.5) | 174 | (57.8) | 1.97 | (1.29–2.99) | 1.87 | (1.23–2.85) |
C | 278 | (26.8) | 117 | (32.5) | 2.01 | (1.33–3.04) | 1.92 | (1.27–2.91) | 206 | (24.7) | 85 | (28.2) | 2.12 | (1.34–3.37) | 2.03 | (1.28–3.23) |
D | 12 | (1.2) | 6 | (1.7) | 2.79 | (0.94–8.24) | 2.50 | (0.84–7.48) | 8 | (1.0) | 5 | (1.7) | 3.71 | (1.09–12.66) | 3.30 | (0.95–11.42) |
Study 2 | ||||||||||||||||
VAS (mean) - Boyd categories (combining >50–75% and >75%) | ||||||||||||||||
≥ 0–10% | 193 | (19.0) | 34 | (10.1) | 1.00 | (referent) | 1.00 | (referent) | 180 | (18.7) | 32 | (9.7) | 1.00 | (referent) | 1.00 | (referent) |
> 10–25% | 401 | (39.5) | 103 | (30.5) | 1.61 | (1.05–2.49) | 1.55 | (1.00–2.40) | 383 | (39.8) | 100 | (30.4) | 1.61 | (1.03–2.50) | 1.55 | (0.99–2.42) |
> 25–50% | 356 | (35.1) | 154 | (45.6) | 2.92 | (1.89–4.52) | 2.87 | (1.85–4.46) | 329 | (34.2) | 152 | (46.2) | 3.02 | (1.94–4.71) | 2.97 | (1.90–4.67) |
> 50% | 64 | (6.3) | 45 | (13.3) | 5.52 | (3.08–9.91) | 5.45 | (3.00–9.89) | 60 | (6.2) | 45 | (13.7) | 5.65 | (3.12–10.23) | 5.63 | (3.07–10.3) |
Volpara Density Grades 4th Edition | ||||||||||||||||
1 (< 4.5) | 474 | (46.7) | 126 | (37.3) | 1.00 | (referent) | 1.00 | (referent) | 447 | (46.5) | 123 | (37.4) | 1.00 | (referent) | 1.00 | (referent) |
2 (4.5– < 7.5) | 336 | (33.1) | 120 | (35.5) | 1.45 | (1.07–1.96) | 1.44 | (1.06–1.95) | 315 | (32.7) | 118 | (35.9) | 1.44 | (1.06–1.95) | 1.43 | (1.05–1.95) |
3 (7.5– < 15.5) | 167 | (16.5) | 73 | (21.6) | 1.96 | (1.34–2.87) | 2.08 | (1.40–3.08) | 156 | (16.2) | 69 | (21.0) | 1.81 | (1.23–2.67) | 1.92 | (1.29–2.86) |
4 (15.5+) | 37 | (3.6) | 19 | (5.6) | 2.47 | (1.30–4.70) | 2.61 | (1.34–5.10) | 34 | (3.5) | 19 | (5.8) | 2.56 | (1.33–4.91) | 2.73 | (1.38–5.38) |
Volpara Density Grades 5th Edition | ||||||||||||||||
1 (<3.5) | 205 | (20.2) | 47 | (13.9) | 1.00 | (referent) | 1.00 | (referent) | 195 | (20.3) | 47 | (14.3) | 1.00 | (referent) | 1.00 | (referent) |
2 (3.5–<7.5) | 570 | (56.2) | 189 | (55.9) | 1.55 | (1.07–2.24) | 1.53 | (1.06–2.23) | 533 | (55.4) | 184 | (55.9) | 1.51 | (1.04–2.19) | 1.51 | (1.04–2.21) |
3 (7.5–<15.5) | 193 | (19.0) | 78 | (23.1) | 2.09 | (1.33–3.28) | 2.16 | (1.36–3.43) | 181 | (18.8) | 74 | (22.5) | 1.92 | (1.22–3.04) | 1.99 | (1.25–3.17) |
4 (15.5+) | 46 | (4.5) | 24 | (7.1) | 2.92 | (1.53–5.58) | 3.00 | (1.54–5.86) | 43 | (4.5) | 24 | (7.3) | 2.82 | (1.47–5.40) | 2.91 | (1.48–5.72) |
Quantized density (BIRADS) | ||||||||||||||||
1 | 32 | (3.2) | 12 | (3.6) | 1.00 | (referent) | 1.00 | (referent) | 32 | (3.3) | 12 | (3.6) | 1.00 | (referent) | 1.00 | (referent) |
2 | 654 | (64.5) | 197 | (58.5) | 0.81 | (0.39–1.70) | 0.87 | (0.42–1.82) | 616 | (64.0) | 192 | (58.4) | 0.82 | (0.39–1.71) | 0.88 | (0.42–1.83) |
3 | 287 | (28.3) | 108 | (32.0) | 1.05 | (0.49–2.27) | 1.12 | (0.52–2.41) | 267 | (27.8) | 105 | (31.9) | 1.04 | (0.48–2.23) | 1.11 | (0.52–2.39) |
4 | 40 | (3.9) | 20 | (5.9) | 1.51 | (0.59–3.88) | 1.54 | (0.59–4.01) | 37 | (3.8) | 20 | (6.1) | 1.50 | (0.58–3.87) | 1.54 | (0.59–4.02) |
Densitas: BIRADS 4 | ||||||||||||||||
0–24 | 354 | (36.1) | 95 | (28.7) | 1.00 | (referent) | 1.00 | (referent) | 345 | (35.9) | 95 | (28.9) | 1.00 | (referent) | 1.00 | (referent) |
25–50 | 586 | (59.8) | 208 | (62.8) | 1.37 | (1.02–1.83) | 1.34 | (1.00–1.80) | 568 | (59.0) | 207 | (62.9) | 1.37 | (1.02–1.83) | 1.34 | (1.00–1.80) |
51+ | 40 | (4.1) | 28 | (8.5) | 2.94 | (1.65–5.24) | 2.83 | (1.55–5.16) | 39 | (4.1) | 27 | (8.2) | 2.86 | (1.60–5.11) | 2.76 | (1.51–5.05) |
Densitas: BIRADS 5 | ||||||||||||||||
A | 96 | (9.8) | 25 | (7.6) | 1.00 | (referent) | 1.00 | (referent) | 94 | (9.8) | 25 | (7.6) | 1.00 | (referent) | 1.00 | (referent) |
B | 574 | (58.6) | 185 | (57.9) | 1.25 | (0.77–2.01) | 1.20 | (0.74–1.94) | 558 | (58.0) | 185 | (56.2) | 1.25 | (0.77–2.01) | 1.20 | (0.74–1.94) |
C | 294 | (30.0) | 110 | (33.2) | 1.47 | (0.88–2.45) | 1.46 | (0.87–2.45) | 284 | (29.5) | 108 | (32.8) | 1.46 | (0.88–2.44) | 1.45 | (0.87–2.44) |
D | 16 | (1.6) | 11 | (3.3) | 2.90 | (1.14–7.42) | 2.59 | (0.99–6.78) | 16 | (1.7) | 11 | (3.3) | 2.90 | (1.13–7.41) | 2.58 | (0.99–6.76) |