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Table 2 Risk of developing breast cancer by density measures (highest versus the lowest quintilea (referent))

From: A comparison of five methods of measuring mammographic density: a case-control study

  

Subset with data for all methodsb

 

Univariate

Adjustedc

Univariate

Adjustedc

 

OR

95% CI

OR

95% CI

OR

95% CI

OR

95% CI

Study 1

 

1.00

(referent)

1.00

(referent)

1.00

(referent)

1.00

(referent)

 VAS (%)

4.45

(2.77–7.15)

4.37

(2.72–7.03)

5.61

(3.29–9.56)

5.44

(3.18–9.29)

 Volpara gland volume (cm3)

2.13

(1.40–3.24)

2.09

(1.37–3.18)

2.00

(1.24–3.21)

1.97

(1.22–3.18)

 Volpara breast density (%)

2.44

(1.57–3.80)

2.42

(1.56–3.78)

2.38

(1.45–3.91)

2.41

(1.46–3.97)

 Cumulus dense area (cm2)

2.11

(1.32–3.38)

2.15

(1.34–3.45)

2.08

(1.28–3.27)

2.12

(1.30–3.45)

 Cumulus breast density (%)

2.09

(1.29–3.40)

2.12

(1.30–3.45)

2.20

(1.32–3.64)

2.23

(1.34–3.71)

 Quantra gland volume (cm3)

0.86

(0.58–1.30)

0.83

(0.55–1.25)

0.72

(0.45–1.15)

0.71

(0.44–1.13)

 Quantra breast density (%)

1.05

(0.70–1.59)

1.02

(0.67–1.54)

1.11

(0.70–1.77)

1.08

(0.68–1.72)

 Densitas dense area (cm2)

1.44

(0.96–2.16)

1.41

(0.93–2.12)

1.62

(1.01–2.59)

1.61

(1.00–2.58)

 Densitas breast density (%)

2.30

(1.50–3.52)

2.17

(1.41–3.33)

2.19

(1.35–3.56)

2.10

(1.29–3.41)

Study 2

 

1.00

(referent)

1.00

(referent)

1.00

(referent)

1.00

(referent)

 VAS (%)

4.54

(2.86–7.22)

4.48

(2.79–7.18)

4.41

(2.76–7.06)

4.36

(2.70–7.04)

 Volpara gland volume (cm3)

2.72

(1.79–4.14)

2.66

(1.74–4.08)

2.71

(1.77–4.14)

2.65

(1.72–4.09)

 Volpara breast density (%)

2.78

(1.74–4.44)

2.87

(1.77–4.64)

2.61

(1.62–4.19)

2.71

(1.67–4.39)

 Quantra gland volume (cm3)

1.36

(0.90–2.06)

1.28

(0.84–1.95)

1.32

(0.87–2.01)

1.24

(0.80–1.90)

 Quantra breast density (%)

1.32

(0.86–2.03)

1.32

(0.85–2.05)

1.30

(0.84–2.00)

1.32

(0.85–2.05)

 Densitas dense area (cm2)

2.34

(1.56–3.52)

2.23

(1.48–3.38)

2.29

(1.50–3.50)

2.14

(1.40–3.29)

 Densitas breast density (%)

2.45

(1.57–3.82)

2.34

(1.50–3.68)

2.44

(1.56–3.80)

2.34

(1.49–3.66)

  1. OR odds ratio, CI confidence interval, VAS visual analogue scale, results in italics indicate statistically significant results (p<0.05)
  2. aQuintiles based on distribution amongst controls
  3. bStudy 1: 239 cases with 3 controls, 62 with 2 controls and 2 with 1 control; study 2: 296 cases with 3 controls, 31 with 2 controls and 2 with 1 control
  4. cAdjusted for Tyrer-Cuzick score; study 2 also adjusted for parity
  5. Figures in italics denote statistically significant results p<0.01