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Table 4 Adjusteda odds ratio (OR) and 95% confidence interval (CI) for joint effect of BMI at age 18 years and recent BMI in relation to risk of breast cancer overall and luminal-like subtype in premenopausal women

From: Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis

BMI at age 18 years, kg/m2 Recent BMI, kg/m2 Controls All cases luminal-like (ER+ and/or PR+)
Number Number OR (95% CI) Number OR (95% CI)
Overall     
 < 20.0 < 25.0 472 952 Referent 540 Referent
 < 20.0 25.0–29.9 96 184 0.93 (0.70–1.24) 92 0.79 (0.56–1.13)
 < 20.0 ≥ 30.0 20 51 1.21 (0.69–2.13) 24 0.99 (0.50–1.96)
 20.0–24.9 < 25.0 265 555 1.03 (0.85–1.25) 311 1.00 (0.79–1.26)
 20.0–24.9 25.0–29.9 171 302 0.87 (0.69–1.10) 151 0.77 (0.58–1.02)
 20.0–24.9 ≥ 30.0 107 210 0.86 (0.65–1.13) 115 0.84 (0.60–1.17)
 ≥  25.0 < 25.0 21 38 0.89 (0.50–1.58) 17 0.65 (0.32–1.35)
 ≥  25.0 25.0–29.9 32 47 0.75 (0.46–1.22) 26 0.79 (0.43–1.44)
 ≥  25.0 ≥ 30.0 73 88 0.54 (0.38–0.78) 40 0.46 (0.29–0.73)
Restricted to studies in which cases’ ER/PR/HER2 status determined in a central laboratory     
 < 20.0 < 25.0 342 448 Referent 183 Referent
 < 20.0 25.0–29.9 70 86 0.94 (0.66–1.35) 31 0.79 (0.49–1.29)
 <20.0 ≥ 30.0 16 21 1.03 (0.52–2.05) 6 0.67 (0.25–1.83)
 20.0–24.9 < 25.0 186 253 1.05 (0.83–1.34) 103 1.03 (0.75–1.42)
 20.0–24.9 25.0–29.9 132 148 0.86 (0.65–1.15) 55 0.75 (0.51–1.11)
 20.0–24.9 ≥ 30.0 81 89 0.78 (0.55–1.11) 37 0.79 (0.50–1.25)
 ≥ 25.0 < 25.0 15 23 1.09 (0.55–2.16) 8 0.83 (0.33–2.08)
 ≥ 25.0 25.0–29.9 27 23 0.68 (0.38–1.22) 11 0.76 (0.36–1.62)
 ≥ 25.0 ≥ 30.0 58 41 0.52 (0.33–0.81) 15 0.46 (0.25–0.86)
Restricted to invasive cases     
 < 20.0 < 25.0 472 849 Referent 485 Referent
 < 20.0 25.0–29.9 96 169 0.94 (0.70–1.26) 86 0.83 (0.58–1.20)
 < 20.0 ≥ 30.0 20 51 1.35 (0.77–2.38) 24 1.13 (0.56–2.28)
 20.0–24.9 < 25.0 265 506 1.04 (0.85–1.27) 287 1.03 (0.81–1.32)
 20.0–24.9 25.0–29.9 171 286 0.92 (0.72–1.17) 143 0.84 (0.62–1.13)
 20.0–24.9 ≥ 30.0 107 201 0.89 (0.67–1.18) 114 0.94 (0.67–1.34)
 ≥ 25.0 < 25.0 21 33 0.87 (0.48–1.59) 14 0.58 (0.27–1.26)
 ≥ 25.0 25.0–29.9 32 44 0.80 (0.48–1.32) 25 0.89 (0.48–1.66)
 ≥ 25.0 ≥ 30.0 73 85 0.58 (0.40–0.84) 40 0.53 (0.33–0.85)
  1. Abbreviations: ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor-2, BMI body mass index
  2. aORs obtained from multivariable polychotomous unconditional logistic regression models with adjustment for source study, study site, race, education, reference age, first-degree breast cancer family history, age at menarche, number of completed pregnancies, lifetime recreational physical activity, alcohol intake, cigarette smoking status, and oral contraceptive use
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Breast Cancer Research

ISSN: 1465-542X

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