Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis

Huiyan Ma; Giske Ursin; Xinxin Xu; Eunjung Lee; Kayo Togawa; Kathleen E. Malone; Polly A. Marchbanks; Jill A. McDonald; Michael S. Simon; Suzanne G. Folger; Yani Lu; Jane Sullivan-Halley; Dennis M. Deapen; Michael F. Press; Leslie Bernstein

doi:10.1186/s13058-017-0931-5

Table 3 Adjusted^a odds ratio (OR) and 95% confidence interval (CI) for breast cancer overall, triple negative breast cancer, and luminal-like subtype associated with BMI in premenopausal white women and premenopausal African-American women

From: Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis

	All cases		Triple negative (ER–/PR–/HER2–)		Luminal-like (ER+ and/or PR+)
	Number	OR (95% CI)	Number	OR (95% CI)	Number	OR (95% CI)
Premenopausal white women
BMI at age 18 years, kg/m²
< 20.0	946	Referent	108	Referent	553	Referent
20.0–24.9	793	1.01 (0.84–1.22)	91	0.92 (0.66–1.30)	470	1.03 (0.83–1.28)
≥ 25.0	121	0.76 (0.53–1.10)	12	0.53 (0.26–1.09)	64	0.73 (0.47–1.13)
Per 5 kg/m² increase		0.86 (0.73–1.02)		0.61 (0.44–0.86)		0.87 (0.71–1.06)
P value		0.08		0.004		0.16
			P value for homogeneity of slope coefficients between two subtypes = 0.04
Recent BMI, kg/m²
< 25.0	1274	Referent	136	Referent	754	Referent
25.0–29.9	373	0.87 (0.69–1.10)	51	1.30 (0.87–1.93)	205	0.78 (0.59–1.02)
≥ 30.0	213	0.72 (0.53–0.97)	24	1.00 (0.57–1.75)	128	0.71 (0.50–1.01)
Per 5 kg/m² increase		0.95 (0.86–1.05)		1.12 (0.94–1.34)		0.94 (0.83–1.06)
P value		0.32		0.19		0.28
			P value for homogeneity of slope coefficients between two subtypes = 0.04
Premenopausal African-American women
BMI at age 18 years, kg/m²
< 20.0	241	Referent	52	Referent	103	Referent
20.0–24.9	274	0.98 (0.72–1.33)	53	0.92 (0.56–1.50)	107	0.90 (0.61–1.35)
≥ 25.0	52	0.66 (0.40–1.13)	13	0.71 (0.31–1.65)	19	0.60 (0.29–1.24)
Per 5 kg/m² increase		0.79 (0.62–1.00)		0.78 (0.54–1.15)		0.74 (0.54–1.03)
P value		0.05		0.21		0.07
			P value for homogeneity of slope coefficients between two subtypes = 0.80
Recent BMI, kg/m²
< 25.0	271	Referent	58	Referent	114	Referent
25.0–29.9	160	0.92 (0.66–1.29)	29	0.79 (0.45–1.37)	64	0.93 (0.60–1.44)
≥ 30.0	136	1.02 (0.68–1.53)	31	1.09 (0.58– 2.05)	51	0.94 (0.55–1.59)
Per 5 kg/m² increase		1.08 (0.92–1.25)		1.13 (0.90–1.43)		1.04 (0.85–1.28)
P value		0.35		0.30		0.69
			P value for homogeneity of slope coefficients between two subtypes = 0.53

Abbreviations: ER estrogen receptor, PR progesterone receptor, HER2, human epidermal growth factor receptor-2, BMI body mass index
^aORs obtained from multivariable polychotomous unconditional logistic regression models with mutual adjustment of BMI at age 18 years and recent BMI and with adjustment for source study, study site, education, reference age, first-degree breast cancer family history, age at menarche, number of completed pregnancies, lifetime recreational physical activity, alcohol intake, cigarette smoking status, and oral contraceptive use

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