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Table 3 Adjusteda odds ratio (OR) and 95% confidence interval (CI) for breast cancer overall, triple negative breast cancer, and luminal-like subtype associated with BMI in premenopausal white women and premenopausal African-American women

From: Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis

  All cases Triple negative (ER–/PR–/HER2–) Luminal-like (ER+ and/or PR+)
Number OR (95% CI) Number OR (95% CI) Number OR (95% CI)
Premenopausal white women  
 BMI at age 18 years, kg/m2     
  < 20.0 946 Referent 108 Referent 553 Referent
  20.0–24.9 793 1.01 (0.84–1.22) 91 0.92 (0.66–1.30) 470 1.03 (0.83–1.28)
  ≥ 25.0 121 0.76 (0.53–1.10) 12 0.53 (0.26–1.09) 64 0.73 (0.47–1.13)
  Per 5 kg/m2 increase 0.86 (0.73–1.02)   0.61 (0.44–0.86)   0.87 (0.71–1.06)
  P value   0.08   0.004   0.16
    P value for homogeneity of slope coefficients between two subtypes = 0.04
 Recent BMI, kg/m2     
  < 25.0 1274 Referent 136 Referent 754 Referent
  25.0–29.9 373 0.87 (0.69–1.10) 51 1.30 (0.87–1.93) 205 0.78 (0.59–1.02)
  ≥ 30.0 213 0.72 (0.53–0.97) 24 1.00 (0.57–1.75) 128 0.71 (0.50–1.01)
  Per 5 kg/m2 increase 0.95 (0.86–1.05)   1.12 (0.94–1.34)   0.94 (0.83–1.06)
  P value   0.32   0.19   0.28
    P value for homogeneity of slope coefficients between two subtypes = 0.04
Premenopausal African-American women  
 BMI at age 18 years, kg/m2     
  < 20.0 241 Referent 52 Referent 103 Referent
  20.0–24.9 274 0.98 (0.72–1.33) 53 0.92 (0.56–1.50) 107 0.90 (0.61–1.35)
  ≥ 25.0 52 0.66 (0.40–1.13) 13 0.71 (0.31–1.65) 19 0.60 (0.29–1.24)
  Per 5 kg/m2 increase 0.79 (0.62–1.00)   0.78 (0.54–1.15)   0.74 (0.54–1.03)
  P value   0.05   0.21   0.07
    P value for homogeneity of slope coefficients between two subtypes = 0.80
Recent BMI, kg/m2     
  < 25.0 271 Referent 58 Referent 114 Referent
  25.0–29.9 160 0.92 (0.66–1.29) 29 0.79 (0.45–1.37) 64 0.93 (0.60–1.44)
  ≥ 30.0 136 1.02 (0.68–1.53) 31 1.09 (0.58– 2.05) 51 0.94 (0.55–1.59)
  Per 5 kg/m2 increase 1.08 (0.92–1.25)   1.13 (0.90–1.43)   1.04 (0.85–1.28)
  P value   0.35   0.30   0.69
    P value for homogeneity of slope coefficients between two subtypes = 0.53
  1. Abbreviations: ER estrogen receptor, PR progesterone receptor, HER2, human epidermal growth factor receptor-2, BMI body mass index
  2. aORs obtained from multivariable polychotomous unconditional logistic regression models with mutual adjustment of BMI at age 18 years and recent BMI and with adjustment for source study, study site, education, reference age, first-degree breast cancer family history, age at menarche, number of completed pregnancies, lifetime recreational physical activity, alcohol intake, cigarette smoking status, and oral contraceptive use