Premenopausal
| | | | | | | | | |
BMI at age 18 years, kg/m2
| | | | | | | | | |
< 20.0
|
588
|
1187
|
Referent
|
160
|
Referent
|
656
|
Referent
|
71
|
Referent
|
300
|
Referent
|
20.0–24.9
|
543
|
1067
|
0.99 (0.84–1.16)
|
144
|
0.91 (0.69–1.20)
|
577
|
0.97 (0.81–1.17)
|
55
|
0.82 (0.55–1.22)
|
291
|
1.09 (0.88–1.35)
|
≥ 25.0
|
126
|
173
|
0.72 (0.53–0.96)
|
25
|
0.62 (0.36–1.04)
|
83
|
0.63 (0.44–0.91)
|
6
|
0.36 (0.14–0.92)
|
59
|
1.00 (0.68–1.46)
|
Per 5 kg/m2 increase
|
0.83 (0.73–0.95)
| |
0.68 (0.53–0.87)
| |
0.80 (0.68–0.95)
| |
0.59 (0.40–0.86)
| |
1.00 (0.84–1.19)
|
P value
| |
0.007
| |
0.002
| |
0.008
| |
0.006
| |
0.98
|
| | | |
P value for homogeneity of slope coefficients across three subtypes = 0.15
|
Recent BMI, kg/m2
| | | | | | | | | | |
< 25.0
|
758
|
1545
|
Referent
|
194
|
Referent
|
868
|
Referent
|
80
|
Referent
|
403
|
Referent
|
25.0–29.9
|
299
|
533
|
0.90 (0.74–1.08)
|
80
|
1.07 (0.78–1.47)
|
269
|
0.82 (0.65–1.02)
|
29
|
0.99 (0.61–1.60)
|
155
|
0.92 (0.71–1.17)
|
≥ 30.0
|
200
|
349
|
0.85 (0.67–1.08)
|
55
|
1.12 (0.75–1.67)
|
179
|
0.80 (0.60–1.06)
|
23
|
1.34 (0.75–2.38)
|
92
|
0.75 (0.54–1.03)
|
Per 5 kg/m2 increase
|
1.00 (0.92–1.08)
| |
1.14 (1.00–1.31)
| |
0.97 (0.88–1.07)
| |
1.19 (0.98–1.45)
| |
0.94 (0.84–1.05)
|
P value
| |
0.94
| |
0.06
| |
0.58
| |
0.07
| |
0.26
|
| | | |
P value for homogeneity of slope coefficients across three subtypes = 0.02
|
Postmenopausalb
| | | | | | | | | |
BMI at age 18 years, kg/m2
| | | | | | | | | |
< 20.0
|
522
|
734
|
Referent
|
89
|
Referent
|
358
|
Referent
|
40
|
Referent
|
247
|
Referent
|
20.0–24.9
|
518
|
673
|
0.92 (0.78–1.10)
|
83
|
0.97 (0.69–1.39)
|
326
|
0.94 (0.76–1.17)
|
35
|
0.88 (0.53–1.44)
|
229
|
0.89 (0.70–1.12)
|
≥ 25.0
|
89
|
100
|
0.79 (0.56–1.11)
|
14
|
1.01 (0.52–1.98)
|
56
|
0.99 (0.65–1.50)
|
5
|
0.76 (0.27–2.14)
|
25
|
0.51 (0.31–0.85)
|
Per 5 kg/m2 increase
|
0.98 (0.85–1.14)
| |
0.98 (0.73–1.32)
| |
1.12 (0.94–1.35)
| |
0.76 (0.48–1.20)
| |
0.86 (0.70–1.05)
|
P value
| |
0.81
| |
0.89
| |
0.21
| |
0.23
| |
0.14
|
| | | |
P value for homogeneity of slope coefficients across three subtypes = 0.20
|
Recent BMI, kg/m2
| | | | | | | | | | |
< 25.0
|
513
|
747
|
Referent
|
83
|
Referent
|
390
|
Referent
|
36
|
Referent
|
238
|
Referent
|
25.0–29.9
|
353
|
435
|
0.95 (0.78–1.16)
|
64
|
1.11 (0.76–1.63)
|
193
|
0.88 (0.69–1.12)
|
28
|
1.23 (0.71–2.12)
|
150
|
0.93 (0.71–1.21)
|
≥ 30.0
|
263
|
325
|
1.09 (0.86–1.39)
|
39
|
0.95 (0.59–1.55)
|
157
|
1.19 (0.89–1.60)
|
16
|
1.11 (0.55–2.25)
|
113
|
1.03 (0.75–1.41)
|
Per 5 kg/m2 increase
|
0.97 (0.90–1.06)
| |
0.97 (0.82–1.15)
| |
0.98 (0.89–1.09)
| |
1.06 (0.83–1.34)
| |
0.95 (0.85–1.07)
|
P value
|
0.54
| |
0.74
| |
0.74
| |
0.66
| |
0.39
|
| | |
P value for homogeneity of slope coefficients across three subtypes = 0.83
|
Postmenopausal/never used MHT
| | | | | | | | | |
Recent BMI, kg/m2
| | | | | | | | | | |
< 25.0
|
186
|
283
|
Referent
|
33
|
Referent
|
148
|
Referent
|
15
|
Referent
|
87
|
Referent
|
25.0–29.9
|
150
|
181
|
0.94 (0.68–1.29)
|
27
|
0.92 (0.50–1.71)
|
74
|
0.82 (0.55–1.21)
|
11
|
0.98 (0.41–2.34)
|
69
|
1.06 (0.70–1.61)
|
≥ 30.0
|
130
|
186
|
1.39 (0.98–1.99)
|
20
|
0.96 (0.50–2.00)
|
86
|
1.55 (1.00–2.41)
|
9
|
1.20 (0.44–3.30)
|
71
|
1.42 (0.90–2.25)
|
Per 5 kg/m2 increase
|
1.07 (0.95–1.21)
| |
0.99 (0.77–1.27)
| |
1.07 (0.92–1.25)
| |
1.10 (0.77–1.56)
| |
1.10 (0.94–1.28)
|
P value
| |
0.27
| |
0.94
| |
0.36
| |
0.60
| |
0.26
|
| | | |
P value for homogeneity of slope coefficients across three subtypes = 0.81
|
Postmenopausal/ever used MHT
| | | | | | | | | |
Recent BMI, kg/m2
| | | | | | | | | | |
< 25.0
|
327
|
464
|
Referent
|
50
|
Referent
|
242
|
Referent
|
21
|
Referent
|
151
|
Referent
|
25.0–29.9
|
203
|
254
|
0.93 (0.72–1.21)
|
37
|
1.12 (0.67–1.87)
|
119
|
0.89 (0.65–1.22)
|
17
|
1.41 (0.68–2.90)
|
81
|
0.86 (0.60–1.22)
|
≥ 30.0
|
133
|
139
|
0.86 (0.62–1.20)
|
19
|
0.87 (0.44–1.69)
|
71
|
0.94 (0.63–1.42)
|
7
|
0.91 (0.33–2.50)
|
42
|
0.75 (0.47–1.19)
|
Per 5 kg/m2 increase
|
0.90 (0.79–1.01)
| |
0.96 (0.75–1.21)
| |
0.92 (0.79–1.06)
| |
1.01 (0.71–1.42)
| |
0.82 (0.69–0.98)
|
P value
| | |
0.07
| |
0.71
| |
0.24
| |
0.98
| |
0.03
|
| | | | |
P value for homogeneity of slope coefficients across three subtypes = 0.85
|