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Table 2 Adjusteda odds ratio (OR) and 95% confidence interval (CI) for breast cancer overall and ER/PR/HER2-defined subtypes associated with BMI in premenopausal women and postmenopausal women

From: Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis

  Controls All cases Triple negative (ER–/PR–/HER2–) Luminal-like (ER+ and/or PR+) HER2-enriched (ER–/PR–/HER2+) Unclassified
Number Number OR (95% CI) Number OR (95% CI) Number OR (95% CI) Number OR (95% CI) Number OR (95% CI)
Premenopausal          
 BMI at age 18 years, kg/m2          
  < 20.0 588 1187 Referent 160 Referent 656 Referent 71 Referent 300 Referent
  20.0–24.9 543 1067 0.99 (0.84–1.16) 144 0.91 (0.69–1.20) 577 0.97 (0.81–1.17) 55 0.82 (0.55–1.22) 291 1.09 (0.88–1.35)
  ≥ 25.0 126 173 0.72 (0.53–0.96) 25 0.62 (0.36–1.04) 83 0.63 (0.44–0.91) 6 0.36 (0.14–0.92) 59 1.00 (0.68–1.46)
  Per 5 kg/m2 increase 0.83 (0.73–0.95)   0.68 (0.53–0.87)   0.80 (0.68–0.95)   0.59 (0.40–0.86)   1.00 (0.84–1.19)
  P value   0.007   0.002   0.008   0.006   0.98
     P value for homogeneity of slope coefficients across three subtypes = 0.15
 Recent BMI, kg/m2           
  < 25.0 758 1545 Referent 194 Referent 868 Referent 80 Referent 403 Referent
  25.0–29.9 299 533 0.90 (0.74–1.08) 80 1.07 (0.78–1.47) 269 0.82 (0.65–1.02) 29 0.99 (0.61–1.60) 155 0.92 (0.71–1.17)
  ≥ 30.0 200 349 0.85 (0.67–1.08) 55 1.12 (0.75–1.67) 179 0.80 (0.60–1.06) 23 1.34 (0.75–2.38) 92 0.75 (0.54–1.03)
  Per 5 kg/m2 increase 1.00 (0.92–1.08)   1.14 (1.00–1.31)   0.97 (0.88–1.07)   1.19 (0.98–1.45)   0.94 (0.84–1.05)
  P value   0.94   0.06   0.58   0.07   0.26
     P value for homogeneity of slope coefficients across three subtypes = 0.02
Postmenopausalb          
 BMI at age 18 years, kg/m2          
  < 20.0 522 734 Referent 89 Referent 358 Referent 40 Referent 247 Referent
  20.0–24.9 518 673 0.92 (0.78–1.10) 83 0.97 (0.69–1.39) 326 0.94 (0.76–1.17) 35 0.88 (0.53–1.44) 229 0.89 (0.70–1.12)
  ≥ 25.0 89 100 0.79 (0.56–1.11) 14 1.01 (0.52–1.98) 56 0.99 (0.65–1.50) 5 0.76 (0.27–2.14) 25 0.51 (0.31–0.85)
  Per 5 kg/m2 increase 0.98 (0.85–1.14)   0.98 (0.73–1.32)   1.12 (0.94–1.35)   0.76 (0.48–1.20)   0.86 (0.70–1.05)
  P value   0.81   0.89   0.21   0.23   0.14
     P value for homogeneity of slope coefficients across three subtypes = 0.20
 Recent BMI, kg/m2           
  < 25.0 513 747 Referent 83 Referent 390 Referent 36 Referent 238 Referent
  25.0–29.9 353 435 0.95 (0.78–1.16) 64 1.11 (0.76–1.63) 193 0.88 (0.69–1.12) 28 1.23 (0.71–2.12) 150 0.93 (0.71–1.21)
  ≥ 30.0 263 325 1.09 (0.86–1.39) 39 0.95 (0.59–1.55) 157 1.19 (0.89–1.60) 16 1.11 (0.55–2.25) 113 1.03 (0.75–1.41)
  Per 5 kg/m2 increase 0.97 (0.90–1.06)   0.97 (0.82–1.15)   0.98 (0.89–1.09)   1.06 (0.83–1.34)   0.95 (0.85–1.07)
  P value 0.54   0.74   0.74   0.66   0.39
    P value for homogeneity of slope coefficients across three subtypes = 0.83
Postmenopausal/never used MHT          
 Recent BMI, kg/m2           
  < 25.0 186 283 Referent 33 Referent 148 Referent 15 Referent 87 Referent
  25.0–29.9 150 181 0.94 (0.68–1.29) 27 0.92 (0.50–1.71) 74 0.82 (0.55–1.21) 11 0.98 (0.41–2.34) 69 1.06 (0.70–1.61)
  ≥ 30.0 130 186 1.39 (0.98–1.99) 20 0.96 (0.50–2.00) 86 1.55 (1.00–2.41) 9 1.20 (0.44–3.30) 71 1.42 (0.90–2.25)
  Per 5 kg/m2 increase 1.07 (0.95–1.21)   0.99 (0.77–1.27)   1.07 (0.92–1.25)   1.10 (0.77–1.56)   1.10 (0.94–1.28)
  P value   0.27   0.94   0.36   0.60   0.26
     P value for homogeneity of slope coefficients across three subtypes = 0.81
Postmenopausal/ever used MHT          
 Recent BMI, kg/m2           
  < 25.0 327 464 Referent 50 Referent 242 Referent 21 Referent 151 Referent
  25.0–29.9 203 254 0.93 (0.72–1.21) 37 1.12 (0.67–1.87) 119 0.89 (0.65–1.22) 17 1.41 (0.68–2.90) 81 0.86 (0.60–1.22)
  ≥ 30.0 133 139 0.86 (0.62–1.20) 19 0.87 (0.44–1.69) 71 0.94 (0.63–1.42) 7 0.91 (0.33–2.50) 42 0.75 (0.47–1.19)
  Per 5 kg/m2 increase 0.90 (0.79–1.01)   0.96 (0.75–1.21)   0.92 (0.79–1.06)   1.01 (0.71–1.42)   0.82 (0.69–0.98)
  P value    0.07   0.71   0.24   0.98   0.03
      P value for homogeneity of slope coefficients across three subtypes = 0.85
  1. Abbreviations: ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor-2, BMI body mass index, MHT menopausal hormone therapy
  2. aORs obtained from multivariable polychotomous unconditional logistic regression models with mutual adjustment of BMI at age 18 years and recent BMI and with adjustment for source study, study site, race, education, reference age, first-degree breast cancer family history, age at menarche, number of completed pregnancies, lifetime recreational physical activity, alcohol intake, cigarette smoking status, and oral contraceptive use
  3. bModel described (a) is additionally adjusted for MHT use