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Table 2 Adjusteda odds ratio (OR) and 95% confidence interval (CI) for breast cancer overall and ER/PR/HER2-defined subtypes associated with BMI in premenopausal women and postmenopausal women

From: Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis

 

Controls

All cases

Triple negative (ER–/PR–/HER2–)

Luminal-like (ER+ and/or PR+)

HER2-enriched (ER–/PR–/HER2+)

Unclassified

Number

Number

OR (95% CI)

Number

OR (95% CI)

Number

OR (95% CI)

Number

OR (95% CI)

Number

OR (95% CI)

Premenopausal

         

 BMI at age 18 years, kg/m2

         

  < 20.0

588

1187

Referent

160

Referent

656

Referent

71

Referent

300

Referent

  20.0–24.9

543

1067

0.99 (0.84–1.16)

144

0.91 (0.69–1.20)

577

0.97 (0.81–1.17)

55

0.82 (0.55–1.22)

291

1.09 (0.88–1.35)

  ≥ 25.0

126

173

0.72 (0.53–0.96)

25

0.62 (0.36–1.04)

83

0.63 (0.44–0.91)

6

0.36 (0.14–0.92)

59

1.00 (0.68–1.46)

  Per 5 kg/m2 increase

0.83 (0.73–0.95)

 

0.68 (0.53–0.87)

 

0.80 (0.68–0.95)

 

0.59 (0.40–0.86)

 

1.00 (0.84–1.19)

  P value

 

0.007

 

0.002

 

0.008

 

0.006

 

0.98

    

P value for homogeneity of slope coefficients across three subtypes = 0.15

 Recent BMI, kg/m2

          

  < 25.0

758

1545

Referent

194

Referent

868

Referent

80

Referent

403

Referent

  25.0–29.9

299

533

0.90 (0.74–1.08)

80

1.07 (0.78–1.47)

269

0.82 (0.65–1.02)

29

0.99 (0.61–1.60)

155

0.92 (0.71–1.17)

  ≥ 30.0

200

349

0.85 (0.67–1.08)

55

1.12 (0.75–1.67)

179

0.80 (0.60–1.06)

23

1.34 (0.75–2.38)

92

0.75 (0.54–1.03)

  Per 5 kg/m2 increase

1.00 (0.92–1.08)

 

1.14 (1.00–1.31)

 

0.97 (0.88–1.07)

 

1.19 (0.98–1.45)

 

0.94 (0.84–1.05)

  P value

 

0.94

 

0.06

 

0.58

 

0.07

 

0.26

    

P value for homogeneity of slope coefficients across three subtypes = 0.02

Postmenopausalb

         

 BMI at age 18 years, kg/m2

         

  < 20.0

522

734

Referent

89

Referent

358

Referent

40

Referent

247

Referent

  20.0–24.9

518

673

0.92 (0.78–1.10)

83

0.97 (0.69–1.39)

326

0.94 (0.76–1.17)

35

0.88 (0.53–1.44)

229

0.89 (0.70–1.12)

  ≥ 25.0

89

100

0.79 (0.56–1.11)

14

1.01 (0.52–1.98)

56

0.99 (0.65–1.50)

5

0.76 (0.27–2.14)

25

0.51 (0.31–0.85)

  Per 5 kg/m2 increase

0.98 (0.85–1.14)

 

0.98 (0.73–1.32)

 

1.12 (0.94–1.35)

 

0.76 (0.48–1.20)

 

0.86 (0.70–1.05)

  P value

 

0.81

 

0.89

 

0.21

 

0.23

 

0.14

    

P value for homogeneity of slope coefficients across three subtypes = 0.20

 Recent BMI, kg/m2

          

  < 25.0

513

747

Referent

83

Referent

390

Referent

36

Referent

238

Referent

  25.0–29.9

353

435

0.95 (0.78–1.16)

64

1.11 (0.76–1.63)

193

0.88 (0.69–1.12)

28

1.23 (0.71–2.12)

150

0.93 (0.71–1.21)

  ≥ 30.0

263

325

1.09 (0.86–1.39)

39

0.95 (0.59–1.55)

157

1.19 (0.89–1.60)

16

1.11 (0.55–2.25)

113

1.03 (0.75–1.41)

  Per 5 kg/m2 increase

0.97 (0.90–1.06)

 

0.97 (0.82–1.15)

 

0.98 (0.89–1.09)

 

1.06 (0.83–1.34)

 

0.95 (0.85–1.07)

  P value

0.54

 

0.74

 

0.74

 

0.66

 

0.39

   

P value for homogeneity of slope coefficients across three subtypes = 0.83

Postmenopausal/never used MHT

         

 Recent BMI, kg/m2

          

  < 25.0

186

283

Referent

33

Referent

148

Referent

15

Referent

87

Referent

  25.0–29.9

150

181

0.94 (0.68–1.29)

27

0.92 (0.50–1.71)

74

0.82 (0.55–1.21)

11

0.98 (0.41–2.34)

69

1.06 (0.70–1.61)

  ≥ 30.0

130

186

1.39 (0.98–1.99)

20

0.96 (0.50–2.00)

86

1.55 (1.00–2.41)

9

1.20 (0.44–3.30)

71

1.42 (0.90–2.25)

  Per 5 kg/m2 increase

1.07 (0.95–1.21)

 

0.99 (0.77–1.27)

 

1.07 (0.92–1.25)

 

1.10 (0.77–1.56)

 

1.10 (0.94–1.28)

  P value

 

0.27

 

0.94

 

0.36

 

0.60

 

0.26

    

P value for homogeneity of slope coefficients across three subtypes = 0.81

Postmenopausal/ever used MHT

         

 Recent BMI, kg/m2

          

  < 25.0

327

464

Referent

50

Referent

242

Referent

21

Referent

151

Referent

  25.0–29.9

203

254

0.93 (0.72–1.21)

37

1.12 (0.67–1.87)

119

0.89 (0.65–1.22)

17

1.41 (0.68–2.90)

81

0.86 (0.60–1.22)

  ≥ 30.0

133

139

0.86 (0.62–1.20)

19

0.87 (0.44–1.69)

71

0.94 (0.63–1.42)

7

0.91 (0.33–2.50)

42

0.75 (0.47–1.19)

  Per 5 kg/m2 increase

0.90 (0.79–1.01)

 

0.96 (0.75–1.21)

 

0.92 (0.79–1.06)

 

1.01 (0.71–1.42)

 

0.82 (0.69–0.98)

  P value

  

0.07

 

0.71

 

0.24

 

0.98

 

0.03

     

P value for homogeneity of slope coefficients across three subtypes = 0.85

  1. Abbreviations: ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor-2, BMI body mass index, MHT menopausal hormone therapy
  2. aORs obtained from multivariable polychotomous unconditional logistic regression models with mutual adjustment of BMI at age 18 years and recent BMI and with adjustment for source study, study site, race, education, reference age, first-degree breast cancer family history, age at menarche, number of completed pregnancies, lifetime recreational physical activity, alcohol intake, cigarette smoking status, and oral contraceptive use
  3. bModel described (a) is additionally adjusted for MHT use
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