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Table 1 Characteristics of breast cancer case-patient participants and control participants by study

From: Body mass index at age 18 years and recent body mass index in relation to risk of breast cancer overall and ER/PR/HER2-defined subtypes in white women and African-American women: a pooled analysis

  Overall Women’s CARE Study Women’s BCIS Study Women’s LIFE Study
Number of cases (%) Number of controls (%) Number of cases (%) Number of controlsa (%) Number of cases (%) Number of cases (%) Number of controls (%)
Number of participants 3934 2386 1873 1982 517 1544 404
Subtype of breast cancer
 Unclassified 1151 691 182 278
 Classified 2783 1182 335 1266
  Triple negative (ER–/PR–/HER2–) 515 (18.5) 329 (27.8) 21 (6.3) 165 (13.0)
  Luminal-like (ER+ and/or PR+) 2056 (73.9)   758 (64.1)   277 (82.7) 1021 (80.7)  
  HER2-enriched (ER–/PR–/HER2+) 212 (7.6) 95 (8.0) 37 (11.0) 80 (6.3)
Mean age at reference date, years (SD) 47.3 (7.4) 47.9 (8.1) 48.9 (8.5) 48.8 (8.4) 51.5 (7.3) 44.0 (3.9) 43.5 (3.8)
Menopausal status
 Premenopausal 2427 (61.7) 1257 (52.7) 929 (49.6) 927 (46.8) 203 (39.3) 1295 (83.9) 330 (81.7)
 Postmenopausal 1507 (38.3) 1129 (47.3) 944 (50.4) 1055 (53.2) 314 (60.7) 249 (16.1) 74 (18.3)
  Never used MHT 650 (43.1) 466 (41.3) 409 (43.3) 430 (40.8) 107 (34.1) 134 (53.8) 36 (48.7)
  Ever used MHT 857 (56.9) 663 (58.7) 535 (56.7) 625 (59.2) 207 (65.9) 115 (46.2) 38 (51.3)
Race
 White 2849 (72.4) 1503 (63.0) 1056 (56.4) 1134 (57.2) 435 (84.1) 1358 (88.0) 369 (91.3)
 African-American 1085 (27.6) 883 (37.0) 817 (43.6) 848 (42.8) 82 (15.9) 186 (12.0) 35 (8.7)
BMI at age 18 years, kg/m2
 < 20.0 1921 (48.8) 1110 (46.5) 882 (47.1) 906 (45.7) 286 (55.3) 753 (48.8) 204 (50.5)
 20.0–24.9 1740 (44.2) 1061 (44.5) 848 (45.3) 893 (45.1) 207 (40.0) 685 (44.4) 168 (41.6)
 ≥ 25.0 273 (6.9) 215 (9.0) 143 (7.6) 183 (9.2) 24 (4.6) 106 (6.9) 32 (7.9)
Recent BMI, kg/m2
 < 25.0 2292 (58.3) 1271 (53.3) 985 (52.6) 1003 (50.6) 345 (66.7) 962 (62.3) 268 (66.3)
 25.0–29.9 968 (24.6) 652 (27.3) 511 (27.3) 570 (28.8) 115 (22.2) 342 (22.2) 82 (20.3)
 ≥ 30.0 674 (17.1) 463 (19.4) 377 (20.1) 409 (20.6) 57 (11.0) 240 (15.5) 54 (13.4)
  1. Abbreviations: ER estrogen receptor, PR progesterone receptor, HER2, human epidermal growth factor receptor-2, BMI body mass index, CARE Contraceptive and Reproductive Experiences, BCIS Breast Carcinoma in situ, LIFE Learning the Influence of Family and Environment, MHT menopausal hormone therapy
  2. aIncluding those who also served as controls for the Women’s BCIS Study