Inherited factors contribute to an inverse association between preeclampsia and breast cancer

Breast Cancer Research

Table 4 Association between preeclampsia and stratus mammographic density among women in the KARMA cohort (N = 43,844)

Condition	Number	Percent density (95% CI)
Condition	Number	Model 1	Model 2
Preeclampsia (woman herself)
No	41,583	REF	REF
Yes	2261	-4.72 (-5.45; -3.99)	-2.04 (-2.65; -1.43)
Having a sister with a diagnosis of preeclampsia^a
No	3296	REF	REF
Yes	204	-3.51 (-6.12; -0.99)	-2.76 (-4.96; -0.56)

Model 1 adjusted for age at mammography (continuous). Model 2 further adjusted for menopausal status, weight status category, age at menarche, number of births, age at first birth, irregular menstrual cycles, physical activity at age 18 years, education level, smoking status, alcohol consumption, and body shape at age 18 years
^aWe linked the KARMA cohort to the Multi-Generation Register to obtain information on sister relationships among these women, while considering the age of the women in this screening cohort (mostly 40–74 years old). Analysis was restricted to women with a sister in KARMA cohort

ISSN: 1465-542X