Inherited factors contribute to an inverse association between preeclampsia and breast cancer

Breast Cancer Research

Table 3 Association between genetic predisposition to breast cancer and preeclampsia in women without breast cancer

			OR (95% CI)
	Number with non-PE	Number with PE	Model 1	Model 2
Sisters in the nationwide cohort (N = 644,483)^a
Having sisters with breast cancer
No	592,547	32,302	1.00 (REF)	1.00 (REF)
Yes	18,785	849	0.83 (0.77; 0.88)	0.89 (0.83; 0.96)
Genotyped women in the KARMA cohort (N = 9263)^b
Percentiles of breast cancer polygenic risk score (woman’s own)
0–40%	3531	175	1.00 (REF)	1.00 (REF)
40–60%	1770	82	0.77 (0.58; 1.03)	0.78 (0.58; 1.04)
60–80%	1743	109	0.78 (0.56; 1.08)	0.78 (0.56; 1.09)
80–90%	866	61	0.77 (0.52; 1.18)	0.77 (0.51; 1.16)
90–100%	881	45	0.55 (0.36; 0.85)	0.56 (0.36; 0.86)
Standardized continuous			0.92 (0.80; 1.05)	0.92 (0.80; 1.06)

Abbreviations: PE preeclampsia, OR odds ratio, CI confidence interval. Significant associations are denoted in bold
^aAnalysis was performed in the Swedish nationwide cohort of pregnant women, and restricted to women with a sister. Model 1 adjusted for number of births. Model 2 further adjusted for age at first birth, weight status categories, smoking status and education level
^bAnalysis was performed among women without breast cancer participating in the KARMA cohort. Model 1 adjusted for number of births and batch effect of genotyping. Model 2 further adjusted for age at first birth, weight status categories, smoking status and education level

ISSN: 1465-542X