| Non-usersa | Users | Unadjusted HR (95% CI) | Adjusted HRb (95% CI) | ||||
---|---|---|---|---|---|---|---|---|
n | Person-years | Deathsc | n | Person-years | Deaths | |||
Main analysis | 18,885 | 105,433 | 2539 | 4784 | 20,722 | 514 | 1.17 (1.07, 1.29) | 1.27 (1.16, 1.40) |
Death definition | ||||||||
 All-cause | 18,885 | 105,433 | 4358 | 4784 | 20,722 | 933 | 1.16 (1.08, 1.25) | 1.33 (1.23, 1.43) |
 Primary or secondary breast cancer cause | 18,885 | 105,433 | 2965 | 4784 | 20,722 | 593 | 1.16 (1.06, 1.27) | 1.28 (1.17, 1.40) |
Exposure definition | ||||||||
 Year before diagnosis | 21,768 | 138,969 | 2810 | 1901 | 10,855 | 243 | 1.09 (0.96, 1.24) | 1.18 (1.03, 1.34) |
 Year after diagnosis | 20,999 | 113,219 | 2700 | 2670 | 12,935 | 353 | 1.11 (1.00, 1.25) | 1.23 (1.10, 1.38) |
Exposure lag | ||||||||
 6 months | 18,541 | 114,762 | 2455 | 5128 | 23,195 | 598 | 1.25 (1.14, 1.36) | 1.36 (1.24, 1.49) |
 2 years | 19,635 | 87,457 | 1912 | 4034 | 16,319 | 360 | 1.14 (1.02, 1.28) | 1.22 (1.09, 1.37) |
Prior antidepressant medicationd | 1769 | 9316 | 258 | 2019 | 8861 | 241 | 1.11 (0.93, 1.33) | 1.21 (1.00, 1.45) |
SSRI vs other antidepressant medication | 3791 | 17,390 | 435 | 4784 | 20,722 | 514 | 1.02 (0.89, 1.15) | 1.06 (0.93, 1.20) |
Tamoxifen use | ||||||||
 Non-user | 11,110 | 52,864 | 1674 | 2790 | 10,678 | 341 | 1.16 (1.03, 1.30) | 1.25 (1.11, 1.41) |
 User | 7775 | 52,569 | 865 | 1994 | 10,044 | 173 | 1.13 (0.96, 1.34) | 1.36 (1.15, 1.61) |
 Adherant usere | 3612 | 26,159 | 489 | 882 | 4645 | 86 | 1.10 (0.87, 1.38) | 1.30 (1.03, 1.65) |
Adjustment | ||||||||
 Excluding ‘previous hot flush’ diagnosisf | 18,885 | 105,433 | 2539 | 4784 | 20,722 | 514 | 1.17 (1.07, 1.29) | 1.24 (1.12, 1.36) |
 CC lifestyleg | 12,568 | 70,673 | 1561 | 3290 | 14,116 | 327 | 1.18 (1.05, 1.33) | 1.24 (1.10, 1.40) |
 MI lifestyle | 18,885 | 105,433 | 2539 | 4784 | 20,722 | 514 | 1.17 (1.07, 1.29) | 1.26 (1.14, 1.38) |
 CC diagnosish | 7388 | 40,419 | 813 | 1863 | 7980 | 164 | 1.13 (0.95, 1.34) | 1.14 (0.96, 1.35) |
 MI diagnosis | 18,885 | 105,433 | 2539 | 4784 | 20,722 | 514 | 1.17 (1.07, 1.29) | 1.27 (1.14, 1.40) |