Skip to main content
Fig 3 | Breast Cancer Research

Fig 3

From: Identifying biomarkers of breast cancer micrometastatic disease in bone marrow using a patient-derived xenograft mouse model

Fig 3

Validation of expressed genes identified from microarray analysis of Washington University Human in Mouse (WHIM)17 bone marrow (BM) samples, by qRT-PCR. Expression of each transcript in the BM of tumor-bearing mice is represented relative to that in non-tumor-bearing humanized NOD-SCID mice (control), using the dd CT method. Since human-specific transcripts were not detected in the BM of control mice, for calculation purposes, a CT value of 40 was assigned. *Animals that developed metastatic tumors. The association between metastatic outcome and gene expression was statistically significant for ALCAM (p = 0.013), GNL3 (p = 0.004), ITGB1BP1 (p = 0.004). ITGB3BP (p = 0.004), MALAT1 (p = 0.023 and CD44 (p = 0.004) analyzed by the Fisher exact test

Back to article page