Table 3 Risk and crude and adjusted odds ratios for blood transfusion within 14 days of surgery among 22,238 breast cancer patients, according to use of selected prescription drugs and stratified by surgery type
Mastectomy | Breast-conserving surgery | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Transfused patients, N | All patients, N | Risk (%) | Crude OR (95% CI) | Adjusted OR* (95% CI) | Transfused patients, N | All patients, N | Risk (%) | Crude OR (95% CI) | Adjusted OR* (95% CI) | ||
Aspirin | |||||||||||
Non-users | 178 | 6406 | 2.8 | 1.0 (ref) | 1.0 | 54 | 14,496 | 0.4 | 1.0 | 1.0 | p = 0.87 |
Users | 37 | 529 | 7.0 | 2.6 (1.8–3.8) | 1.9 (1.3–2.9) | 10 | 807 | 1.2 | 3.4 (1.7– 6.6) | 1.8 (0.9–3.8) | |
NSAIDs | |||||||||||
Non-users | 187 | 6324 | 3.0 | 1.0 | 1.0 | 60 | 14,140 | 0.4 | 1.0 | 1.0 | p = 0.23 |
Users | 28 | 611 | 4.6 | 1.6 (1.1–2.4) | 1.4 (1.0–2.2) | 4 | 1163 | 0.3 | 0.8 (0.3–2.2) | 0.7 (0.3–2.0) | |
SSRIs | |||||||||||
Non-users | 198 | 6551 | 3.0 | 1.0 | 1.0 | 62 | 14,607 | 0.4 | 1.0 | 1.0 | p = 0.23 |
Users | 17 | 384 | 4.4 | 1.5 (0.9–2.5) | 1.3 (0.8–2.2) | 2 | 696 | 0.3 | 0.7 (0.2– 2.8) | 0.5 (0.1–2.2) | |
Statins | |||||||||||
Non-users | 189 | 6300 | 3.0 | 1.0 | 1.0 | 59 | 13,909 | 0.4 | 1.0 | 1.0 | p = 0.29 |
Users | 26 | 635 | 4.1 | 1.4 (0.9–2.1) | 1.1 (0.7–1.7) | 5 | 1394 | 0.4 | 0.8 (0.3–2.1) | 0.6 (0.2–1.6) | |