Table 1 Baseline characteristics of 22,238 breast cancer surgery patients according to use of selected prescription drugs, Denmark, 2005–2012
All patients | Aspirin | NSAIDs | SSRIs | Statins | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Nonusers | Users | Nonusers | Users | Nonusers | Users | Nonusers | Users | |||||||||||
N | % | N | % | N | % | N | % | N | % | N | % | N | % | N | % | N | % | |
Total | 22,238 | 100.0 | 20,902 | 100.0 | 1336 | 100.0 | 20,464 | 100.0 | 1774 | 100.0 | 21,158 | 100.0 | 1080 | 100.0 | 20,209 | 100.0 | 2029 | 100.0 |
Age at diagnosis (years) | ||||||||||||||||||
35–49 | 3794 | 17.1 | 3778 | 18.1 | 16 | 1.2 | 3606 | 17.6 | 188 | 10.6 | 3648 | 17.2 | 146 | 13.5 | 3743 | 18.5 | 51 | 2.5 |
50–59 | 6102 | 27.4 | 5958 | 28.5 | 144 | 10.8 | 5661 | 27.7 | 441 | 24.9 | 5806 | 27.4 | 296 | 27.4 | 5734 | 28.4 | 368 | 18.1 |
60–69 | 7831 | 35.2 | 7335 | 35.1 | 496 | 37.1 | 7209 | 35.2 | 622 | 35.1 | 7467 | 35.3 | 364 | 33.7 | 6843 | 33.9 | 988 | 48.7 |
70–79 | 3233 | 14.5 | 2808 | 13.4 | 425 | 31.8 | 2844 | 13.9 | 389 | 21.9 | 3051 | 14.4 | 182 | 16.9 | 2748 | 13.6 | 485 | 23.9 |
> =80 | 1278 | 5.7 | 1023 | 4.9 | 255 | 19.1 | 1144 | 5.6 | 134 | 7.6 | 1186 | 5.6 | 92 | 8.5 | 1141 | 5.6 | 137 | 6.8 |
Stage | ||||||||||||||||||
I | 10,161 | 45.7 | 9580 | 45.8 | 581 | 43.5 | 9347 | 45.7 | 814 | 45.9 | 9689 | 45.8 | 472 | 43.7 | 9192 | 45.5 | 969 | 47.8 |
II | 9587 | 43.1 | 8992 | 43.0 | 595 | 44.5 | 8842 | 43.2 | 745 | 42.0 | 9118 | 43.1 | 469 | 43.4 | 8739 | 43.2 | 848 | 41.8 |
III | 2490 | 11.2 | 2330 | 11.1 | 160 | 12.0 | 2275 | 11.1 | 215 | 12.1 | 2351 | 11.1 | 139 | 12.9 | 2278 | 11.3 | 212 | 10.4 |
Charlson comorbidity score | ||||||||||||||||||
0 | 18,863 | 84.8 | 18,131 | 86.7 | 732 | 54.8 | 17,405 | 85.1 | 1458 | 82.2 | 18,064 | 85.4 | 799 | 74.0 | 17,500 | 86.6 | 1363 | 67.2 |
1–2 | 3074 | 13.8 | 2560 | 12.2 | 514 | 38.5 | 2782 | 13.6 | 292 | 16.5 | 2829 | 13.4 | 245 | 22.7 | 2498 | 12.4 | 576 | 28.4 |
> =3 | 301 | 1.4 | 211 | 1.0 | 90 | 6.7 | 277 | 1.4 | 24 | 1.4 | 265 | 1.3 | 36 | 3.3 | 211 | 1.0 | 90 | 4.4 |
Specific comobidities of interest | ||||||||||||||||||
Myocardial infarction | 197 | 0.9 | 96 | 0.5 | 101 | 7.6 | 185 | 0.9 | 12 | 0.7 | 178 | 0.8 | 19 | 1.8 | 116 | 0.6 | 81 | 4.0 |
Congestive heart failure | 211 | 0.9 | 146 | 0.7 | 65 | 4.9 | 189 | 0.9 | 22 | 1.2 | 194 | 0.9 | 17 | 1.6 | 164 | 0.8 | 47 | 2.3 |
Diabetes I and II | 652 | 2.9 | 484 | 2.3 | 168 | 12.6 | 589 | 2.9 | 63 | 3.6 | 595 | 2.8 | 57 | 5.3 | 392 | 1.9 | 260 | 12.8 |
Diabetes with end organ damage | 239 | 1.1 | 159 | 0.8 | 80 | 6.0 | 214 | 1.0 | 25 | 1.4 | 212 | 1.0 | 27 | 2.5 | 142 | 0.7 | 97 | 4.8 |
Pre-operative hemoglobin concentration | ||||||||||||||||||
No data | 9137 | 41.1 | 8603 | 41.2 | 534 | 40.0 | 8401 | 41.1 | 736 | 41.5 | 8672 | 41.0 | 465 | 43.1 | 8308 | 41.1 | 829 | 40.9 |
< 7.4 mmol/L | 660 | 3.0 | 578 | 2.8 | 82 | 6.1 | 577 | 2.8 | 83 | 4.7 | 602 | 2.8 | 58 | 5.4 | 578 | 2.9 | 82 | 4.0 |
> =7.4 mmol/L | 12,441 | 55.9 | 11,721 | 56.1 | 720 | 53.9 | 11,486 | 56.1 | 955 | 53.8 | 11,884 | 56.2 | 557 | 51.6 | 11,323 | 56.0 | 1118 | 55.1 |
Type of primary surgery | ||||||||||||||||||
Mastectomy | 6935 | 31.2 | 6406 | 30.6 | 529 | 39.6 | 6324 | 30.9 | 611 | 34.4 | 6551 | 31.0 | 384 | 35.6 | 6300 | 31.2 | 635 | 31.3 |
Breast-conserving surgery | 15,303 | 68.8 | 14,496 | 69.4 | 807 | 60.4 | 14,140 | 69.1 | 1163 | 65.6 | 14,607 | 69.0 | 696 | 64.4 | 13,909 | 68.8 | 1394 | 68.7 |