Table 3 Selected single-nucleotide polymorphisms in relation to risk of breast cancer, stratified by vitamin D level
From: SNPs related to vitamin D and breast cancer risk: a case-control study
SNP (proxy for GWAS) | Low vitamin Da | High vitamin Da | |||
|---|---|---|---|---|---|
Allele | Frequency in cases/control subjects (n = 684) | ORb of breast cancer (95% CI) | p Value for interaction | Frequency in cases/control subjects (n = 659) | ORb of breast cancer (95% CI) |
rs12239582 (rs12144344) | |||||
CC | 127/97 | 1.00 | 99/89 | 1.00 | |
CA | 176/168 | 0.85 (0.59–1.21) | 0.73 | 164/172 | 0.91 (0.62–1.33) |
AA | 60/56 | 0.83 (0.52–1.34) | 0.30 | 74/61 | 1.16 (0.72–1.87) |
rs705117 | |||||
CC | 278/226 | 1.00 | 251/235 | 1.00 | |
CT | 76/88 | 0.65 (0.45–0.95) | 0.28 | 84/84 | 0.87 (0.60–1.27) |
TT | 9/7 | 1.14 (0.41–3.22) | 0.36 | 2/3 | 0.45 (0.66–3.11) |
rs7041 | |||||
AA | 120/93 | 1.00 | 141/129 | 1.00 | |
AC | 169/172 | 0.70 (0.48–1.00) | 0.14 | 161/147 | 1.05 (0.74–1.47) |
CC | 74/56 | 1.11 (0.69–1.76) | 0.15 | 35/46 | 0.65 (0.38–1.11) |
rs2282679 (rs17467825) | |||||
GG | 174/168 | 1.00 | 209/188 | 1.00 | |
GT | 155/123 | 1.25 (0.89–1.75) | 0.16 | 113/117 | 0.91 (0.65–1.29) |
TT | 33/29 | 1.21 (0.68–2.16) | 0.69 | 14/15 | 0.92 (0.42–2.04) |
Missing | 1/1 | – | – | 1/2 | – |
rs10485165 | |||||
TT | 267/248 | 1.00 | 262/239 | 1.00 | |
TC | 88/65 | 1.34 (0.91–1.98) | 0.08 | 67/77 | 0.83 (0.56–1.22) |
CC | 8/8 | 0.94 (0.32–2.78) | 0.79 | 8/6 | 1.11 (0.36–3.40) |
rs198300 (rs156299) | |||||
GG | 126/92 | 1.00 | 110/119 | 1.00 | |
GA | 184/160 | 0.82 (0.57–1.18) | 0.25 | 165/154 | 1.06 (0.74–1.52) |
AA | 53/69 | 0.53 (0.33–0.87) | <0.01 | 62/49 | 1.38 (0.85–2.23) |
rs4751058 | |||||
AA | 267/229 | 1.00 | 235/225 | 1.00 | |
AG | 89/85 | 0.91 (0.63–1.329 | 0.37 | 96/87 | 1.06 (0.74–1.52) |
GG | 7/7 | 1.00 (0.33–3.03) | 0.42 | 6/10 | 0.47 (0.16–1.38) |
rs12295888 (rs12287212) | |||||
CC | 146/124 | 1.00 | 157/139 | 1.00 | |
CT | 169/152 | 0.94 (0.66–1.33) | 0.88 | 154/148 | 0.86 (0.61–1.20) |
TT | 48/45 | 1.01 (0.60–1.67) | 0.33 | 26/35 | 0.65 (0.36–1.17) |
rs1007392 | |||||
GG | 129/102 | 1.00 | 140/127 | 1.00 | |
GA | 177/160 | 0.87 (0.61–1.25) | 0.71 | 159/151 | 0.91 (0.64–1.29) |
AA | 57/58 | 0.81 (0.50–1.30) | 0.98 | 38/44 | 0.79 (0.47-1.34) |
Missing | 0/1 | – | – | – | |
rs2060793 (rs10741657) | |||||
AA | 134/112 | 1.00 | 89/105 | 1.00 | |
AG | 168/160 | 0.95 (0.67–1.35) | 0.10 | 174/149 | 1.35 (0.93–1.97) |
GG | 61/49 | 0.99 (0.61–1.60) | 0.44 | 74/68 | 1.31 (0.83–2.08) |
rs7944926 (rs12785878) | |||||
AA | 167/130 | 1.00 | 180/163 | 1.00 | |
AG | 158/141 | 0.88 (0.62–1.24) | 0.75 | 137/135 | 0.93 (0.66–1.29) |
GG | 38/50 | 0.58 (0.35–0.98) | 0.49 | 20/24 | 0.78 (0.40–1.51) |
rs3829251 | |||||
AA | 218/184 | 1.00 | 222/213 | 1.00 | |
AG | 126/116 | 0.95 (0.68–1.34) | 0.56 | 110/100 | 1.07 (0.76–1.51) |
GG | 19/21 | 0.74 (0.37–1.49) | 0.62 | 5/9 | 0.57 (0.18–1.79) |
rs2302190 | |||||
CC | 236/215 | 1.00 | 229/237 | 1.00 | |
CT | 114/97 | 1.03 (0.73–1.47) | 0.49 | 97/79 | 1.27 (0.88–1.84) |
TT | 12/8 | 1.36 (0.51–3.60) | 0.52 | 9/4 | 2.11 (0.61–7.30) |
Missing | 1/1 | – | – | 2/2 | – |