Fig. 5

Annexin-1 (ANXA1)-regulated phosphoproteome network. a Transcription factors predicted to be enriched among the upregulated and downregulated proteins are visualized as a treemap. The size of the squares indicates the number of transcriptional targets and the color of the squares represent enrichment factor. Only significantly enriched (p value <0.05) transcription factors are shown. b Schematic network of the ANXA1-regulated phosphoproteome interacting with the predicted transcription factors. Proteins were grouped into their respective functional process or localizations for visualization purpose. The stress fibers are depicted as pink lines and the focal adhesions are marked as blue ovals. ANXA1-responsive phosphoproteins with increased site abundance are shown with brown-filled nodes and those with decreased site abundance are represented by green-filled nodes. Diamond-shaped nodes represent kinases. Nodes with only border colors denote predicted upregulated (brown) and downregulated (green) transcription factors