Fig. 4

Annexin-1 (ANXA1)-altered kinase profiles. a Experimentally curated kinase-substrate relationships for ANXA1-responsive phosphoproteins are visualized as a kinome network. The specific sites that are phosphorylated by the kinase are shown as red (increased abundance) or blue (decreased abundance) edges. High-scoring protein-protein interactions are additionally mapped onto the network. Yellow nodes represent all kinases. b Kinase-substrate enrichment analysis was carried out for predicted upstream kinases. Positive activity score indicates higher activity and negative scores correspond to lower activity. Those kinases enriched with p value <0.05 are indicated with red and blue dots.