From: Association between mammographic breast density and histologic features of benign breast disease
 | Age-adjusted and BMI-adjusted | Fully adjusteda | |||||
---|---|---|---|---|---|---|---|
Covariate | Total N = 3400 | Non-dense N = 1237 | Dense N = 2163 | Odds ratio (95% CI) | p valueb | Odds ratio (95% CI) | P value |
Age of BBD | Â | Â | Â | Â | <.001 | Â | <.001 |
 Ordinal effect | 3400 | 57.7 (12.7) | 51.7 (12.5) | 0.96 (0.96, 0.97) |  | 0.96 (0.96, 0.97) |  |
BMI at biopsy | Â | Â | Â | Â | <.001 | Â | <.001 |
 Ordinal effect | 3400 | 28.8 (7.0) | 25.8 (5.3) | 0.92 (0.91, 0.93) |  | 0.93 (0.91, 0.94) |  |
HT ever/never | Â | Â | Â | Â | <.001 | Â | 0.002 |
 No | 1341 | 529 (39.4%) | 812 (60.6%) | 1.00 (ref) |  | 1.00 (ref) |  |
 Yes | 2059 | 708 (34.4%) | 1351 (65.6%) | 1.30 (1.12, 1.52) |  | 1.29 (1.10, 1.50) | |
ADH | Â | Â | Â | Â | 0.896 | Â | Â |
 Absent | 3339 | 1213 (36.3%) | 2126 (63.7%) | 1.00 (ref) |  |  |  |
 Present | 61 | 24 (39.3%) | 37 (60.7%) | 1.04 (0.60, 1.78) |  |  | |
ALH | Â | Â | Â | Â | 0.001 | Â | 0.050 |
 Absent | 3246 | 1196 (36.8%) | 2050 (63.2%) | 1.00 (ref) |  | 1.00 (ref) |  |
 Present | 154 | 41 (26.6%) | 113 (73.4%) | 1.88 (1.28, 2.74) |  | 1.49 (1.00, 2.21) | |
Involution | Â | Â | Â | Â | <.001 | Â | 0.006 |
 Complete | 992 | 479 (48.3%) | 513 (51.7%) | 1.00 (ref) |  | 1.00 (ref) |  |
 Partial | 1920 | 644 (33.5%) | 1276 (66.5%) | 1.36 (1.14, 1.61) |  | 1.03 (0.86, 1.25) | |
 None | 488 | 114 (23.4%) | 374 (76.6%) | 1.57 (1.18, 2.07) |  | 1.55 (1.16, 2.07) | |
Fibrosis | Â | Â | Â | Â | <.001 | Â | <.001 |
 Absent | 1233 | 605 (49.1%) | 628 (50.9%) | 1.00 (ref) |  | 1.00 (ref) |  |
 Present | 2167 | 632 (29.2%) | 1535 (70.8%) | 2.27 (1.95, 2.65) |  | 2.22 (1.87, 2.62) | |
CCH/FEA | Â | Â | Â | Â | <.001 | Â | 0.036 |
 Absent | 2273 | 894 (39.3%) | 1379 (60.7%) | 1.00 (ref) |  | 1.00 (ref) |  |
 Present | 1127 | 343 (30.4%) | 784 (69.6%) | 1.71 (1.45, 2.01) |  | 1.30 (1.02, 1.66) | |
Sclerosing adenosis | Â | Â | Â | Â | <.001 | Â | 0.531 |
 Absent | 2269 | 899 (39.6%) | 1370 (60.4%) | 1.00 (ref) |  | 1.00 (ref) |  |
 Present | 1131 | 338 (29.9%) | 793 (70.1%) | 1.59 (1.35, 1.86) |  | 1.07 (0.86, 1.33) | |
Cyst | Â | Â | Â | Â | <.001 | Â | 0.981 |
 Absent | 1379 | 557 (40.4%) | 822 (59.6%) | 1.00 (ref) |  | 1.00 (ref) |  |
 Present | 2021 | 680 (33.6%) | 1341 (66.4%) | 1.45 (1.24, 1.68) |  | 1.00 (0.84, 1.19) | |
Usual ductal hyperplasia | Â | Â | Â | Â | <.001 | Â | 0.544 |
 None | 1984 | 750 (37.8%) | 1234 (62.2%) | 1.00 (ref) |  | 1.00 (ref) |  |
 Mild | 493 | 179 (36.3%) | 314 (63.7%) | 1.15 (0.93, 1.43) |  | 0.87 (0.69, 1.09) | |
 Moderate | 678 | 227 (33.5%) | 451 (66.5%) | 1.54 (1.26, 1.87) |  | 1.05 (0.83, 1.34) | |
 Florid | 245 | 81 (33.1%) | 164 (66.9%) | 1.62 (1.20, 2.19) |  | 0.98 (0.69, 1.38) | |
Calcifications | Â | Â | Â | Â | <.001 | Â | 0.325 |
 Absent | 1738 | 647 (37.2%) | 1091 (62.8%) | 1.00 (ref) |  | 1.00 (ref) |  |
 Present | 1662 | 590 (35.5%) | 1072 (64.5%) | 1.34 (1.15, 1.56) |  | 1.09 (0.92, 1.29) | |
Fibroadenoma | Â | Â | Â | Â | 0.065 | Â | Â |
 Absent | 2433 | 864 (35.5%) | 1569 (64.5%) | 1.00 (ref) |  |  |  |
 Present | 966 | 372 (38.5%) | 594 (61.5%) | 0.86 (0.73, 1.01) |  |  | |
Intra-ductal papilloma | Â | Â | Â | Â | 0.111 | Â | Â |
 Absent | 3128 | 1138 (36.4%) | 1990 (63.6%) | 1.00 (ref) |  |  |  |
 Present | 262 | 94 (35.9%) | 168 (64.1%) | 1.25 (0.95, 1.66) |  |  | |
Radial scars | Â | Â | Â | Â | 0.052 | Â | Â |
 Absent | 3168 | 1166 (36.8%) | 2002 (63.2%) | 1.00 (ref) |  |  |  |
 Present | 230 | 71 (30.9%) | 159 (69.1%) | 1.35 (1.00, 1.82) |  |  | |
Duct ectasia | Â | Â | Â | Â | 0.440 | Â | Â |
 Absent | 2917 | 1065 (36.5%) | 1852 (63.5%) | 1.00 (ref) |  |  |  |
 Present | 481 | 172 (35.8%) | 309 (64.2%) | 1.09 (0.88, 1.34) |  |  | |
Mucocele-like lesions | Â | Â | Â | Â | 0.559 | Â | Â |
 Absent | 3356 | 1224 (36.5%) | 2132 (63.5%) | 1.00 (ref) |  |  |  |
 Present | 39 | 13 (33.3%) | 26 (66.7%) | 1.23 (0.61, 2.50) |  |  |