Fig. 2

miR-105 and miR-93-3p promote cisplatin/CCRT resistance in TNBC cells. To determine the effect of miRNAs on cisplatin response, four oncomiRs were individually (a) overexpressed in HCC70 cells or (b) silenced in BT-549 cells and cells were treated with indicated cisplatin doses for 72 hours before cell viability was measured by the MTT assay. c Co-overexpression or co-knockdown of miR-105/93-3p in HCC70 and BT-549, respectively, was performed and cells were treated with the indicated cisplatin doses for 72 hours to before viability was measured with the MTT assay. d Cells were treated with the indicated doses of radiation combined with 5 μM cisplatin. CCRT response was measured in miR-105/93-3p co-overexpressing-HCC70 cells or co-silenced-BT-549 cells. The cell viabilities were normalized to control. Mean ± SEM; ^* P < 0.05, ^*** P <0.001