Table 4 Overall survival; multivariable analysis including Z-4OHtam, Z-endoxifen, and AAS

Z-4OHtam

Z-4OHtam

> 3.26 nM

1

Adjusted^†

0.81

0.66–0.99

0.040

≤ 3.26 nM

4.86

1.88–12.54

0.001

Unadjusted

0.85

0.70–1.02

0.077

pT

1

1

2

2.59

1.11–6.05

0.028

pN

Negative

1

Positive

2.89

1.12–7.49

0.029

Chemotherapy

Yes

1

No

2.34

0.90– 6.11

0.083

Z-endoxifen

Z–endoxifen

> 9.00 nM

1

Adjusted^†

0.99

0.96–1.02

0.365

≤ 9.00 nM

5.65

2.00–16.00

0.001

Unadjusted

0.99

0.97–1.02

0.580

pT

1

1

2

2.44

1.08–5.49

0.032

pN

Negative

1

Positive

2.40

0.99–5.80

0.052

Chemotherapy

Yes

1

No

3.41

1.24–9.39

0.017

AAS

AAS

> 16.7

1

Adjusted^†

0.99

0.97–1.01

0.313

≤ 16.7

8.39

2.90–24.26

<0.001

Unadjusted

0.99

0.98–1.10

0.532

pT

1

1

2

2.60

1.15–5.91

0.022

pN

Negative

1

Positive

3.40

1.26–9.15

0.016

Chemotherapy

Yes

1

No

2.67

1.03–6.94

0.044