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Table 3 Univariable survival analyses of breast cancer-specific survival and overall survival

From: Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

 

Breast cancer-specific survival

Overall survival

Factor

Event/at risk

HR

95% CI

P

Event/at risk

HR

95% CI

P

Tumor size

 pT1

7/44

1

  

11/44

1

  

 pT2

9/42

1.47

0.55–3.96

0.439

16/42

1.70

0.79–3.67

0.169

Node status

 pN0

4/33

1

  

9/33

1

  

 pN+

12/52

2.00

0.64 –6.19

0.222

18/52

1.33

0.60–2.96

0.484

Histological grade

 1

3/16

1

  

6/16

1

  

 2

10/57

0.94

0.26–3.42

0.924

16/57

0.76

0.30–1.94

0.564

 3

3/11

1.48

0.30–7.35

0.631

5/11

1.30

0.40–4.28

0.661

Histological grade

 1 + 2

13/73

1

  

22/73

1

  

 3

3/11

1.56

0.44–5.46

0.335

5/11

1.61

0.61–4.25

0.335

Age

 < 55 years

7/35

1

  

7/35

1

  

 ≥ 55 years

9/51

0.93

0.35–2.51

0.890

20/51

2.09

0.89–4.95

0.085

ER

 ≥ 10%

15/75

1

  

26/75

1

  

 < 10%

1/7

0.63

0.08–4.73

0.646

1/7

0.36

0.05–2.65

0.294

PR

 ≥ 10%

11/55

1

  

17/55

1

  

 < 10%

4/27

0.72

0.23–2.25

0.566

9/27

0.98

0.43–2.19

0.951

Chemotherapy*

 Yes

6/30

1

  

6/30

1

  

 No

10/56

0.93

0.34–2.57

0.893

21/56

1.97

0.80–4.89

0.135

AAS

 > 16.7

13/79

1

  

21/79

1

  

 ≤ 16.7

3/7

3.81

1.07–13.56

0.026

6/7

5.37

2.14–13.51

< 0.001

Z-4OHtam

 > 3.26 nM

12/76

1

  

20/76

1

  

 ≤ 3.26 nM

4/10

3.56

1.14–11.11

0.020

7/10

4.05

1.70–9.64

0.001

Z-endoxifen

 > 9.00 nM

13/79

1

  

22/79

1

  

 ≤ 9.00 nM

3/7

3.73

1.05–13.23

0.029

5/7

4.03

1.51–10.74

0.003

  1. * Did the patients receive chemotherapy according to the treatment guidelines at the time
  2. AAS antiestrogenic activity score, CI confidence interval, ER estrogen receptor, HR hazard ratio, pN pathologic node status, PR progesterone receptor, pT pathologic tumor size