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Table 1 Racial differences in gene expression among white (n = 478) and black (n = 495) women, overall and by breast cancer subtype, from CBCS Phase 3, 2008–2013

From: Race-associated biological differences among luminal A and basal-like breast cancers in the Carolina Breast Cancer Study

 

Overall (n = 973)

Luminal A (n = 372)

Basal-like (n = 248)

Gene

Relative expression (95% CI)a

P

Relative expression (95% CI)a

P

Relative expression (95% CI)a

P

ACOX2

0.99 (0.87–1.12)

0.849

1.00 (0.86–0.96)

0.958

1.12 (0.79–1.58)

0.539

MUC1

0.72 (0.62–0.83)

<0.001

0.68 (0.56–0.82)

<0.001

0.81 (0.58–1.12)

0.202

FAM177A1

1.00 (0.94–1.06)

0.941

1.00 (0.94–1.07)

0.962

0.98 (0.80–1.20)

0.834

GSTT2

1.41 (1.19–1.68)

<0.001

1.43 (1.10–1.85)

0.008

1.58 (1.07–2.32)

0.020

PSPH

1.00 (0.91–1.10)

0.984

0.98 (0.88–1.10)

0.780

1.13 (0.87–1.46)

0.349

PSPHL

2.38 (2.11–2.67)

<0.001

2.33 (1.95–2.79)

<0.001

1.77 (1.39–2.24)

<0.001

SQLE

1.15 (1.04–1.27)

0.007

1.19 (1.05–1.35)

0.006

0.98 (0.76–1.27)

0.868

TYMS

1.20 (1.11–1.29)

<0.001

1.24 (1.12–1.38)

<0.001

1.08 (0.92–1.26)

0.345

  1. RNA counts were normalized log2-transformed prior to analysis
  2. CI confidence interval
  3. aRelative expression comparing black versus white (referent) women; relative expression is adjusted for age, codeset, and PAM50 subtype, as appropriate
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Breast Cancer Research

ISSN: 1465-542X

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