Table 3 Multivariate analysis of distant disease-free survival and breast cancer-specific survival for the HR+/HER2− patients, including risk of recurrence risk classification

pT

 1

1

1

 2

1.70

0.97–3.00

0.065

1.52

0.91–2.52

0.107

 3-4

2.30

0.86–6.14

0.097

2.41

0.99–4.21

0.054

Grade

 I

1

1

 II

1.47

0.69–3.13

0.319

1.68

0.82–3.42

0.156

 III

1.39

0.56–3.42

0.474

2.35

1.04–5.35

0.041

pN

 0

1

1

 1

1.31

0.61–2.81

0.492

1.22

0.61–2.45

0.578

 2-3

2.27

1.04–4.98

0.040

2.04

0.99–4.21

0.054

Age

  < 55 years

1

1

  ≥ 55 years

0.58

0.30–1.11

0.102

0.63

0.36–1.14

0.130

Systemic treatment

 No

1

1

 Tam

0.99

0.48–2.05

0.982

1.06

0.56–2.03

0.854

 Chemotherapy ± Tam

0.40

0.16–1.02

0.055

0.48

0.21–1.10

0.084

ROR score

 Low

1

1

 Intermediate

2.25

0.77–6.60

0.137

2.25

0.94–5.41

0.070

 High

6.82

2.62–17.81

< 0.001

4.69

2.08–10.55

< 0.001