Training set | Validation set | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Controls | Cases | P value | Controls | Cases | P value | |||||
N (%) | N (%) | N (%) | N (%) | |||||||
Age at consent (years) | 0.9994 | 0.9997 | ||||||||
<50 | 44 | (6) | 16 | (6) | 46 | (5) | 16 | (5) | ||
50–54 | 200 | (25) | 65 | (25) | 193 | (21) | 64 | (20) | ||
55–-59 | 150 | (19) | 51 | (19) | 164 | (18) | 58 | (18) | ||
60–64 | 172 | (22) | 57 | (22) | 286 | (31) | 96 | (30) | ||
65–69 | 166 | (21) | 57 | (22) | 195 | (21) | 67 | (21) | ||
70+ | 55 | (7) | 18 | (7) | 47 | (5) | 16 | (5) | ||
HRT use | 0.2234 | 0.9646 | ||||||||
Unknown | 11 | (1) | 7 | (3) | 22 | (2) | 6 | (2) | ||
Never | 473 | (60) | 171 | (65) | 475 | (51) | 165 | (52) | ||
Previous | 262 | (33) | 72 | (27) | 329 | (35) | 110 | (35) | ||
Current | 41 | (5) | 14 | (5) | 105 | (11) | 36 | (11) | ||
BMI (kg/m2) | 0.9797 | 0.9408 | ||||||||
Unknown | - | - | - | 1 | (0) | |||||
<25 | 241 | (31) | 80 | (30) | 335 | (36) | 117 | (37) | ||
25–29 | 289 | (37) | 96 | (36) | 341 | (37) | 113 | (36) | ||
≥30 | 257 | (33) | 88 | (33) | 255 | (27) | 86 | (27) | ||
Menopausal status | 0.9914 | 0.9887 | ||||||||
Unknown | 16 | (2) | 7 | (3) | 32 | (3) | 12 | (4) | ||
Perimenopausal | 94 | (12) | 32 | (12) | 134 | (14) | 46 | (15) | ||
Postmenopausal | 591 | (75) | 196 | (74) | 698 | (75) | 237 | (75) | ||
Premenopausal | 86 | (11) | 29 | (11) | 67 | (7) | 22 | (7) | ||
Ethnic origin | 0.0411 | 0.2229 | ||||||||
Other/unknown | 38 | (5) | 22 | (8) | 81 | (9) | 35 | (11) | ||
White | 749 | (95) | 242 | (92) | 850 | (91) | 282 | (89) | ||
Parity | 0.8143 | 0.0351 | ||||||||
Unknown | - | - | 1 | (0) | 4 | (1) | ||||
Nulliparous | 97 | (12) | 34 | (13) | 90 | (10) | 44 | (14) | ||
Parous | 690 | (88) | 230 | (87) | 840 | (90) | 269 | (85) | ||
Tyrer-Cuzick (10-year risk, %) (median, Q1–Q3) | 2.73 | (2.19–3.60) | 2.82 | (2.29–3.88) | 0.0028 | 2.68 | (2.09–3.55) | 2.91 | (2.24–4.03) | <0.0001 |
Volumetric PD (median, Q1–Q3) | 5.34 | (4.06–7.35) | 5.88 | (4.62–8.55) | 0.0003 | 4.73 | (3.50–6.92) | 5.31 | (3.79–7.57) | 0.0041 |