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Table 1 Demographics of the training set (cancers detected at first screen on entry to the PROCAS study) and validation set (cancers detected at a subsequent screen or between screening rounds)

From: A novel and fully automated mammographic texture analysis for risk prediction: results from two case-control studies

 

Training set

 

Validation set

 

Controls

Cases

P value

Controls

Cases

P value

N (%)

N (%)

N (%)

N (%)

Age at consent (years)

 

0.9994

 

0.9997

 <50

44

(6)

16

(6)

 

46

(5)

16

(5)

 

 50–54

200

(25)

65

(25)

 

193

(21)

64

(20)

 

 55–-59

150

(19)

51

(19)

 

164

(18)

58

(18)

 

 60–64

172

(22)

57

(22)

 

286

(31)

96

(30)

 

 65–69

166

(21)

57

(22)

 

195

(21)

67

(21)

 

 70+

55

(7)

18

(7)

 

47

(5)

16

(5)

 

HRT use

 

0.2234

 

0.9646

 Unknown

11

(1)

7

(3)

 

22

(2)

6

(2)

 

 Never

473

(60)

171

(65)

 

475

(51)

165

(52)

 

 Previous

262

(33)

72

(27)

 

329

(35)

110

(35)

 

 Current

41

(5)

14

(5)

 

105

(11)

36

(11)

 

BMI (kg/m2)

 

0.9797

 

0.9408

 Unknown

-

 

-

  

-

 

1

(0)

 

 <25

241

(31)

80

(30)

 

335

(36)

117

(37)

 

 25–29

289

(37)

96

(36)

 

341

(37)

113

(36)

 

 ≥30

257

(33)

88

(33)

 

255

(27)

86

(27)

 

Menopausal status

 

0.9914

 

0.9887

 Unknown

16

(2)

7

(3)

 

32

(3)

12

(4)

 

 Perimenopausal

94

(12)

32

(12)

 

134

(14)

46

(15)

 

 Postmenopausal

591

(75)

196

(74)

 

698

(75)

237

(75)

 

 Premenopausal

86

(11)

29

(11)

 

67

(7)

22

(7)

 

Ethnic origin

 

0.0411

 

0.2229

 Other/unknown

38

(5)

22

(8)

 

81

(9)

35

(11)

 

 White

749

(95)

242

(92)

 

850

(91)

282

(89)

 

Parity

 

0.8143

 

0.0351

 Unknown

-

 

-

  

1

(0)

4

(1)

 

 Nulliparous

97

(12)

34

(13)

 

90

(10)

44

(14)

 

 Parous

690

(88)

230

(87)

 

840

(90)

269

(85)

 

Tyrer-Cuzick (10-year risk, %) (median, Q1–Q3)

2.73

(2.19–3.60)

2.82

(2.29–3.88)

0.0028

2.68

(2.09–3.55)

2.91

(2.24–4.03)

<0.0001

Volumetric PD (median, Q1–Q3)

5.34

(4.06–7.35)

5.88

(4.62–8.55)

0.0003

4.73

(3.50–6.92)

5.31

(3.79–7.57)

0.0041

  1. P values, from likelihood-ratio chi-square tests, indicate whether there are significant difference between cases and controls
  2. HRT hormone replacement therapy, BMI body mass index, Q1 25th percentile, Q3 75th percentile, PD percent density