Table 4 Univariate and multivariate Cox regression analysis of overall survival

Protein expression high vs. low

1.53 (1.10–2.12)

0.011

1.23 (0.90–1.68)

0.194

Age at surgery (years)

<0.001

1.06 (1.03–1.09)

<0.001

1.06 (1.03–1.08)

<0.001

Tumor size

<0.001

Not included

Not included

  < 2 cm

 ≥2–-5 cm

 >5 cm

Histology

0.306

Not included

Not included

 Ductal vs. non-ductal

T stage

<0.001

 T1 vs. ≥T2

1.46 (0.88–2.40)

0.141

1.49 (0.90–2.47)

0.123

Grade

<0.001

 I

Reference

Reference

 II

1.69 (0.52–5.49)

0.385

1.77 (0.54–5.76)

0.345

 III

2.40 (0.70–8.23)

0.163

2.95 (0.87–9.99)

0.081

Nodal status

<0.001

 N0 vs. ≥N1

1.86 (1.18–2.92)

0.007

1.85 (1.17–2.92)

0.008

Menopausal status

0.001

 Pre/peri vs. postmenopausal

0.72 (0.28–1.85)

0.489

0.80 (0.31–2.05)

0.64

 ER- vs. ER+

<0.001

Not included

Not included

 PgR- vs. PgR+

<0.001

Not included

Not included

 HER2- vs. HER2+

0.682

Not included

Not included

 HR- vs. HR+

<0.001

0.72 (0.42–1.22)

0.217

0.63 (0.37–1.06)

0.082

Receptor-defined subtypes

<0.001

Not included

Not included

 Luminal A-like

 Luminal B-like (HER2 positive)

 Luminal B-like (HER2 negative)

 HER2 positive (non-luminal-like)

 TNBC