Fig. 2

Unsupervised clustering and analyses based on “diffuse” cluster refinement (a). The heatmap represents metabolism-related protein expression levels of the diffuse target signature after unsupervised hierarchical clustering of 801 tumor specimen. The z scores of log2-transformed protein expression levels are color-coded on a low-to-high scale (green-black-magenta). Annotation bars include receptor-defined subtypes (a), histological grade (b), histology (c), menopausal status (d), nodal status (e) and T stage (f). Statistical analysis of the three patient clusters (blue, yellow, brown) is shown in Additional file 3: Table S1. Kaplan-Meier curves represent the proportion of overall survivors (b) and recurrence-free survivors (c), compared by log-rank test