TY - JOUR AU - Tu, Cheng-Fen AU - Wu, Meng-Ying AU - Lin, Yuh-Charn AU - Kannagi, Reiji AU - Yang, Ruey-Bing PY - 2017 DA - 2017/10/05 TI - FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation JO - Breast Cancer Research SP - 111 VL - 19 IS - 1 AB - Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for signaling receptors involved in many physiological and pathological processes such as cell growth, adhesion, and tumor metastasis. Transforming growth factor-β (TGF-β)-induced epithelial–mesenchymal transition (EMT) regulates the invasion and metastasis of breast tumors. However, whether receptor core fucosylation affects TGF-β signaling during breast cancer progression remains largely unknown. SN - 1465-542X UR - https://doi.org/10.1186/s13058-017-0904-8 DO - 10.1186/s13058-017-0904-8 ID - Tu2017 ER -