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Table 6 Differential expression of alcohol metabolism genes in tumor and tumor-adjacent normal tissues in the NHS and the NHSII

From: Alcohol consumption and breast tumor gene expression

    ER+ tumors vs. tumor-adjacent normal tissues ER- tumors vs. tumor-adjacent normal tissues
Probeset ID Entrez ID Symbol Log2(FC) t valuea FDRb Log2(FC) t valuea FDRb
TC0401141 125 ADH1B −1.33 −21.1 2.92E-61 −1.32 −11.0 1.59E-14
TC0901044 216 ALDH1A1 −0.61 −16.7 2.77E-44 −0.58 −8.6 6.93E-11
TC0401142 126 ADH1C −0.25 −14.6 3.80E-36 −0.29 −7.6 3.08E-09
TC1100272 847 CAT −0.34 −10.2 1.99E-20 −0.32 −4.2 6.20E-04
TC1200702 217 ALDH2 −0.18 −7.0 6.53E-11 −0.20 −4.0 1.01E-03
TC0401137 128 ADH5 −0.11 −4.8 7.69E-06 −0.04 −0.7 6.00E-01
TC1000709 1571 CYP2E1 −0.02 −1.9 8.21E-02 −0.02 −0.6 7.02E-01
  1. ER estrogen receptor, NHS Nurses’ Health Study, FDR false discovery rate, FC fold change
  2. aThe t values were obtained from paired t tests of tumor and adjacent normal tissues: 357 pairs of ER+ tumor and ER+ tumor-adjacent normal tissues, and 86 pairs for ER- tumor and ER- tumor-adjacent normal, respectively
  3. bFDR was calculated across all the 25,979 probes