Alcohol consumption and breast tumor gene expression

Breast Cancer Research

Table 6 Differential expression of alcohol metabolism genes in tumor and tumor-adjacent normal tissues in the NHS and the NHSII

			ER+ tumors vs. tumor-adjacent normal tissues			ER- tumors vs. tumor-adjacent normal tissues
Probeset ID	Entrez ID	Symbol	Log2(FC)	t value^a	FDR^b	Log2(FC)	t value^a	FDR^b
TC0401141	125	ADH1B	−1.33	−21.1	2.92E-61	−1.32	−11.0	1.59E-14
TC0901044	216	ALDH1A1	−0.61	−16.7	2.77E-44	−0.58	−8.6	6.93E-11
TC0401142	126	ADH1C	−0.25	−14.6	3.80E-36	−0.29	−7.6	3.08E-09
TC1100272	847	CAT	−0.34	−10.2	1.99E-20	−0.32	−4.2	6.20E-04
TC1200702	217	ALDH2	−0.18	−7.0	6.53E-11	−0.20	−4.0	1.01E-03
TC0401137	128	ADH5	−0.11	−4.8	7.69E-06	−0.04	−0.7	6.00E-01
TC1000709	1571	CYP2E1	−0.02	−1.9	8.21E-02	−0.02	−0.6	7.02E-01

ER estrogen receptor, NHS Nurses’ Health Study, FDR false discovery rate, FC fold change
^aThe t values were obtained from paired t tests of tumor and adjacent normal tissues: 357 pairs of ER+ tumor and ER+ tumor-adjacent normal tissues, and 86 pairs for ER- tumor and ER- tumor-adjacent normal, respectively
^bFDR was calculated across all the 25,979 probes

ISSN: 1465-542X