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Table 3 Enriched gene setsa by recent alcohol consumptionb in ER+ tumors in the NHS and the NHSII

From: Alcohol consumption and breast tumor gene expression

Pathway-defined gene set

Number of enriched genes

NES

FDR

Upregulated

 REACTOME_NONSENSE_MEDIATED_DECAY_ENHANCED_BY_THE_EXON_JUNCTION_COMPLEX

106

2.56

<0.0001

 REACTOME_INFLUENZA_LIFE_CYCLE

134

2.49

<0.0001

 REACTOME_METABOLISM_OF_RNA

248

2.14

0.001

 REACTOME_NEP_NS2_INTERACTS_WITH_THE_CELLULAR_EXPORT_MACHINERY

26

1.99

0.007

 REACTOME_TRANSPORT_OF_MATURE_MRNA_DERIVED_FROM_AN_INTRONLESS_TRANSCRIPT

31

1.98

0.008

 REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS

26

1.97

0.008

 REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES

61

1.93

0.014

 POSITIVE_REGULATION_OF_TRANSCRIPTION_FROM_RNA_POLYMERASE_II_PROMOTER

61

1.93

0.015

 REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS

31

1.90

0.018

 MRNA_PROCESSING_GO_0006397

67

1.89

0.019

 REACTOME_SYNTHESIS_OF_GLYCOSYLPHOSPHATIDYLINOSITOL_GPI

17

1.89

0.019

 MEIOTIC_CELL_CYCLE

24

1.89

0.020

 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

51

1.86

0.025

 RNA_PROCESSING

159

1.85

0.027

 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

132

1.83

0.028

 REACTOME_METABOLISM_OF_NON_CODING_RNA

45

1.83

0.029

 REACTOME_DOUBLE_STRAND_BREAK_REPAIR

18

1.84

0.030

 PROTEIN_RNA_COMPLEX_ASSEMBLY

60

1.84

0.030

 REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN

26

1.78

0.048

Downregulated

 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT

38

−2.12

0.017

 REACTOME_SMOOTH_MUSCLE_CONTRACTION

21

−2.13

0.024

 REACTOME_MUSCLE_CONTRACTION

40

−2.06

0.025

 KEGG_PPAR_SIGNALING_PATHWAY

58

−2.03

0.025

  1. ER estrogen receptor, NHS Nurses’ Health Study, NES normalized enrichment score, FDR false discovery rate
  2. aOnly gene sets replicated in The Cancer Genome Atlas (TCGA) dataset and FDR <0.05 are shown
  3. bEnriched gene sets for comparison of recent alcohol consumption 10+ vs. 0 g/day