Fig. 5
From: Heterogeneous drug penetrance of veliparib and carboplatin measured in triple negative breast tumors
Visual predictive check (VPC) of platinum adducts observed (dots) and predicted (shaded area shows 95% CI prediction interval and the straight line the typical pharmacokinetic profile) in peripheral blood mononuclear cells (PBMCs) from patients stratified for treatment with single agent (a) at day 1 (left) and combined with a poly(ADP-ribose) polymerase inhibitor (PARPi) (talazoparib (right)), suggesting that platinum adduct formation was not influenced by the PARPi. b VPC stratified for gBRCA patients and non-carriers, showing the results for two individuals. These plots suggest that lower carboplatin adduct formation was observed in patients with BRCA 1/2 mutations (left) compared to non-carriers (right)