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Table 6 Univariate association between peripheral blood biomarkers of aging and reduced RDI

From: Association of pre-chemotherapy peripheral blood pro-inflammatory and coagulation factors with reduced relative dose intensity in women with breast cancer

  RDI ≥ 85% RDI < 85% OR (95% CI) P value
(N = 123) (N = 36)
As continuous variables     
 IL-6 (pg/ml) 2.7 (3.15) 5.7 (7.95) 1.14 (1.04–1.25) 0.006
 D-dimer (μg/ml) 0.7 (0.58) 1.1 (0.57) 2.32 (1.27–4.24) 0.006
 CRP (μg/ml) 5.3 (7.42) 6.4 (9.07) 1.02 (0.97–1.06) 0.47
As categorical variables     
IL-6
 Q 1, 2, 3 98 (79.7%) 22 (61.1%)   
 Q4 25 (20.3%) 14 (38.9%) 2.49 (1.12–5.56) 0.02
D-Dimer
 Q 123 97 (78.9%) 18 (51.4%)   
 Q4 26 (21.1%) 17 (48.6%) 3.52 (1.60–7.78) 0.002
CRP
 Q 123 94 (76.4%) 26 (72.2%)   
 Q 4 29 (23.6%) 10 (27.8%) 1.25 (0.53–2.89) 0.61
IL-6 or D-dimer combinationa
 0 79 (86.8%) 12 (13.2%)   
 1 or 2 44(64.7%) 24 (35.3%) 3.59 (1.64–8.87) 0.001
  1. Continuous variables are presented as mean (SD) and categorical variables as N (%)
  2. RDI relative dose intensity, CRP C-reactive protein
  3. aIL-6 or D-dimer combination: 0 = both markers in lower three quartiles; 1 = 1 of the markers in the 4th quartile; 2 = 2 of the markers in the 4th quartile