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Table 6 Univariate association between peripheral blood biomarkers of aging and reduced RDI

From: Association of pre-chemotherapy peripheral blood pro-inflammatory and coagulation factors with reduced relative dose intensity in women with breast cancer

 

RDI ≥ 85%

RDI < 85%

OR (95% CI)

P value

(N = 123)

(N = 36)

As continuous variables

    

 IL-6 (pg/ml)

2.7 (3.15)

5.7 (7.95)

1.14 (1.04–1.25)

0.006

 D-dimer (μg/ml)

0.7 (0.58)

1.1 (0.57)

2.32 (1.27–4.24)

0.006

 CRP (μg/ml)

5.3 (7.42)

6.4 (9.07)

1.02 (0.97–1.06)

0.47

As categorical variables

    

IL-6

 Q 1, 2, 3

98 (79.7%)

22 (61.1%)

  

 Q4

25 (20.3%)

14 (38.9%)

2.49 (1.12–5.56)

0.02

D-Dimer

 Q 123

97 (78.9%)

18 (51.4%)

  

 Q4

26 (21.1%)

17 (48.6%)

3.52 (1.60–7.78)

0.002

CRP

 Q 123

94 (76.4%)

26 (72.2%)

  

 Q 4

29 (23.6%)

10 (27.8%)

1.25 (0.53–2.89)

0.61

IL-6 or D-dimer combinationa

 0

79 (86.8%)

12 (13.2%)

  

 1 or 2

44(64.7%)

24 (35.3%)

3.59 (1.64–8.87)

0.001

  1. Continuous variables are presented as mean (SD) and categorical variables as N (%)
  2. RDI relative dose intensity, CRP C-reactive protein
  3. aIL-6 or D-dimer combination: 0 = both markers in lower three quartiles; 1 = 1 of the markers in the 4th quartile; 2 = 2 of the markers in the 4th quartile