Toxicity type | Grade 3–4 toxicities | |
---|---|---|
Hematologic | ||
 Anemia | 13 | 38% |
 White blood cell count decreased | 10 | 29% |
 Neutrophil count decreased | 8 | 24% |
 Bleeding | 3 | 9% |
Non-hematologic | ||
 Metabolic abnormalities | 14 | 12% |
 Nausea/vomiting | 13 | 11% |
 Neuropathy | 12 | 10% |
 Mucositis | 9 | 8% |
 Infection | 9 | 8% |
 Fatigue | 9 | 8% |
 Diarrhea | 6 | 5% |
 Arrhythmia | 5 | 4% |
 Left ventricular systolic dysfunction | 5 | 4% |
 Pain | 5 | 4% |
 Dehydration | 4 | 3% |
 Allergy | 3 | 2.5% |
 Hypotension | 3 | 2.5% |
 Syncope | 3 | 2.5% |
 Kidney dysfunction | 3 | 2.5% |
 Dizziness | 2 | 1.7% |
 Othersa | 1 | 0.8% |