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Table 4 Multivariable models with Breast Imaging Reporting and Data System breast density, dense breast volume, or both, with and without adjustment for body mass index

From: Combining quantitative and qualitative breast density measures to assess breast cancer risk

  BI-RADS
breast density
Continuous dense
breast volume
BI-RADS breast density + continuous dense breast volume BI-RADS
breast density adjusted for BMI
Continuous dense
breast volume adjusted for BMI
BI-RADS breast density + continuous dense breast volume adjusted for BMI
ORa (95% CI) ORa
(95% CI)
ORa
(95% CI)
ORb
(95% CI)
ORb
(95% CI)
ORb
(95% CI)
BI-RADS breast density
 Almost entirely fat = a 0.74 (0.62–0.89)   0.77 (0.64–0.92) 0.65 (0.54–0.78)   0.69 (0.57–0.84)
 Scattered fibroglandular densities = b 1.00 (reference)   1.00 (reference) 1.00 (reference)   1.00 (reference)
 Heterogeneously dense = c 1.34 (1.16–1.55)   1.17 (1.01–1.36) 1.45 (1.25–1.68)   1.26 (1.07–1.48)
 Extremely dense = d 2.01 (1.61–2.51)   1.63 (1.30–2.05) 2.45 (1.93–3.09)   1.93 (1.50–2.48)
Dense breast volume, ml, per SDc   1.34 (1.26–1.42) 1.26 (1.18–1.35)   1.33 (1.25–1.42) 1.20 (1.11–1.29)
C-statisticd 0.614 (0.598–0.630) 0.623 (0.607–0.639) 0.627 (0.611–0.642) 0.634 (0.618–0.649) 0.630 (0.614–0.645) 0.639 (0.623–0.654)
  1. BI-RADS Breast Imaging Reporting and Data System, BMI Body mass index
  2. aAdjusted for age, race/ethnicity, history of breast biopsy, family history of breast cancer. Statistically significant results are shown in boldface type
  3. bAdjusted for age, race/ethnicity, history of breast biopsy, family history of breast cancer, BMI. Statistically significant results are shown in boldface type
  4. cMeasured with Volpara software, log-transformed
  5. dC-statistic represents the AUROC