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Table 3 Quartile level of WBC DNA methylation and risk of breast cancer

From: White blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)

  Quartiles of DNA methylation
  Q4 (high) Q3 Q2 Q1 (low)
Adjusted ORa 1.0 (referent) 0.89 0.88 0.84
95% CI   (0.6–1.3) (0.6–1.3) (0.6–1.2)
Cases, controls 114, 101 107, 106 102, 102 105, 110
Fully adjusted ORb 1.0 (referent) 0.90 0.87 0.83
95% CI   (0.6–1.3) (0.6–1.3) (0.6–1.2)
Cases, controls 114, 101 107, 106 102, 102 105, 110
  1. WBC white blood cells, Q quartile, OR Odds Ratio
  2. aAdjusted for age, time of entry and date of DNA extraction (previously extracted, newly extracted)
  3. bAdditionally adjusted for race, body mass index, age at menarche, age at first live birth, number of children, type of menopause, age at natural menopause, personal history of benign breast disease, cigarette smoking, alcohol intake, family history of breast cancer, and hormone use