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Table 5 Summary of the in vivo experiments

From: Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

Group Number of mice inoculated Tumors Died early Tissue harvest
468-WT 13 13 0 13
468-shSCR 13 13 0 13
468-shCDH1-B 13 13 0 13
468-shCDH1-D 13 13 01 12
468-pcDNA3 12 09 0 12
468-CDH1 12 12 0 12
  1. sh Short hairpin, SCR Scrambled, WT Wild type
  2. The E-cadherin-modified MDA-MB-468 cell lines were orthotopically inoculated to the right mammary fat pads of severe combined immunodeficiency mice (n = 12–13 per group). The groups inoculated with wild-type MDA-MB-468 (468-WT), 468-shSCR, 468-shCDH1-B, 468-shCDH1-D, and 468-CDH1 developed tumors in all mice. In the 468-pcDNA3 group, 9 of 12 mice developed tumors. One mouse from the 468-shCDH1-D group died before harvest as a result of non-tumor-related causes