Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

Table 5 Summary of the in vivo experiments

Group	Number of mice inoculated	Tumors	Died early	Tissue harvest
468-WT	13	13	0	13
468-shSCR	13	13	0	13
468-shCDH1-B	13	13	0	13
468-shCDH1-D	13	13	01	12
468-pcDNA3	12	09	0	12
468-CDH1	12	12	0	12

sh Short hairpin, SCR Scrambled, WT Wild type
The E-cadherin-modified MDA-MB-468 cell lines were orthotopically inoculated to the right mammary fat pads of severe combined immunodeficiency mice (n = 12–13 per group). The groups inoculated with wild-type MDA-MB-468 (468-WT), 468-shSCR, 468-shCDH1-B, 468-shCDH1-D, and 468-CDH1 developed tumors in all mice. In the 468-pcDNA3 group, 9 of 12 mice developed tumors. One mouse from the 468-shCDH1-D group died before harvest as a result of non-tumor-related causes

ISSN: 1465-542X