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Fig. 5 | Breast Cancer Research

Fig. 5

From: Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

Fig. 5

a Rate of xenograft tumor growth. Individual tumor volumes from each mouse from each group were averaged and plotted against the number days postinoculation. Statistical significance was determined by two-way analysis of variance (ANOVA) with Sidak’s posttest; ** p < 0.001, * p < 0.05. (i) E-cadherin overexpression group. (ii) E-cadherin knockdown group. b The tumor/necrosis ratio. (i) Hematoxylin and eosin staining of xenograft tumors, low magnification. N Necrotic area. Blood vessels are indicated by red arrowhead. Scale bar = 50 μm. (ii) Percentage of viable tumor tissue/remaining tumor mass. Statistical significance was determined by one-way ANOVA; *** p < 0.001

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