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Fig. 10 | Breast Cancer Research

Fig. 10

From: Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

Fig. 10

E-cadherin expression correlates with poor clinical outcome for patients with breast cancer. a Analysis of clinical data of breast cancers separated according to PAM50 intrinsic subtype from a publicly available microarray study [78]. (i) CDH1 expression. **** p > 0.001, ** p < 0.01, by one-way analysis of variance versus basal. (ii) Percentage of patients positive or negative for distant metastasis. (iii) Kaplan-Meier curve depicting the correlation between breast cancer subtype and distant metastasis-free survival. p Value was determined by the log-rank (Mantel-Cox) statistical test. b Breast cancers that did or did not metastasize to distant sites were analyzed with respect to E-cadherin expression. (i) Data from Yau et al. [78], the same data source used for figures shown in (a) and (ii) [77]. p Values were determined by Welch’s t test

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