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Fig. 5 | Breast Cancer Research

Fig. 5

From: AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer

Fig. 5

AKT1low quiescent cancer cells (QCCs) in primary tumors from patients with triple negative breast cancer persist after multi-agent, multi-cycle neoadjuvant chemotherapy (NACT). a QCC percentage appeared to increase in primary breast tumor tissue after NACT (p = 0.017) Paired samples are shown by dotted lines. b QCC cluster index is preserved in primary breast tumor tissue after NACT (p = 0.056). c Graphical summary of a and b showing that QCC percentage and clustering persist in post-treatment primary breast tumors after treatment with anthracycline, taxane, platinum-based chemotherapy, and mTOR inhibitors and VEGF inhibitors (red dots, QCCs; blue dots, non-QCCs)

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