Fig. 4From: AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancerAKT1low quiescent cancer cells (QCC) cluster in primary triple negative breast cancer (TNBC) tumor sections and the likelihood of clustering (QCC-cluster index (QCC-CI)) correlates with the QCC percentage (QCC-P). a QCC-CI for control samples (n = 4, black bars), pre-neoadjuvant chemotherapy (NACT) TNBC primary tumor biopsy samples (n = 10, red bars), post-NACT TNBC primary tumor mastectomy samples (n = 15; 1 sample was excluded due to insufficient QCCs to determine QCC-CI, green bars) and metastasis samples (n = 4, blue bars). QCC-P for each patient sample (based on QCC-P of one section per sample) is shown by orange dots. Clinical and pathologic data for each patient is shown adjacent to each sample. Each patient is identified by a unique identifier with sample type designated by the letter suffix e.g. patient BR10614-79 has a biopsy (BR10614-79-B), post-NACT mastectomy sample (BR10614-79-Ma) and metastatic sample (BR10614-79-Me) available. Matched biopsy and mastectomy pairs with residual disease after NACT are labeled bold. Biopsy samples with matched mastectomy samples that underwent pCR are underlined. A patient with matched biopsy, mastectomy and metastasis samples is identified by bold italics. b QCC-CI correlates with QCC-P for control, biopsy, mastectomy and metastasis sections (R = 0.54)Back to article page