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Fig. 4 | Breast Cancer Research

Fig. 4

From: AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer

Fig. 4

AKT1low quiescent cancer cells (QCC) cluster in primary triple negative breast cancer (TNBC) tumor sections and the likelihood of clustering (QCC-cluster index (QCC-CI)) correlates with the QCC percentage (QCC-P). a QCC-CI for control samples (n = 4, black bars), pre-neoadjuvant chemotherapy (NACT) TNBC primary tumor biopsy samples (n = 10, red bars), post-NACT TNBC primary tumor mastectomy samples (n = 15; 1 sample was excluded due to insufficient QCCs to determine QCC-CI, green bars) and metastasis samples (n = 4, blue bars). QCC-P for each patient sample (based on QCC-P of one section per sample) is shown by orange dots. Clinical and pathologic data for each patient is shown adjacent to each sample. Each patient is identified by a unique identifier with sample type designated by the letter suffix e.g. patient BR10614-79 has a biopsy (BR10614-79-B), post-NACT mastectomy sample (BR10614-79-Ma) and metastatic sample (BR10614-79-Me) available. Matched biopsy and mastectomy pairs with residual disease after NACT are labeled bold. Biopsy samples with matched mastectomy samples that underwent pCR are underlined. A patient with matched biopsy, mastectomy and metastasis samples is identified by bold italics. b QCC-CI correlates with QCC-P for control, biopsy, mastectomy and metastasis sections (R = 0.54)

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