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Fig. 3 | Breast Cancer Research

Fig. 3

From: AKT1low quiescent cancer cells persist after neoadjuvant chemotherapy in triple negative breast cancer

Fig. 3

AKT1low quiescent cancer cells (QCC) are heterogeneously and non-randomly distributed throughout primary breast tumors. a Control tumor 3, sections 8–23 arrayed sequentially as a 3D stack of digital tumor maps showing QCCs (red dots) and other tumor cells (blue dots). Stroma, areas of necrosis or areas of poor image quality are excluded (gray areas). QCC percentage (QCC-P) for each section is shown on the left of each plane. QCCs are found in the periphery of some tumor sections but not others (black arrows vs. white arrows). b Summary of QCC-P for each section of control samples 1–4 (red lines) with QCC-density (QCC-P for each × 20 field of view) represented by box and whisker plot for each section. Summary QCC-P and QCC density for each whole tumor sample (mean of all available sections from that tumor) is indicated by bold labels (e.g. Control 3)

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